mavatrep

ChemicalBook > CAS DataBase List > mavatrep

Product Name: mavatrep
CAS No.: 956274-94-5
Chemical Name: mavatrep
Synonyms: CS-1660;mavatrep;Mavatrep(JNJ-39439335);Mavatrep, 10 mM in DMSO;JNJ 39439335;JNJ39439335;(E)-2-(2-(2-(4-(Trifluoromethyl)styryl)-1H-benzo[d]imidazol-6-yl)phenyl)propan-2-ol;(trans)-2-(2-{2-[2-(4-trifluoromethylphenyl)vinyl]-1H-benzimidazol-5-yl}phenyl)propan-2-ol;Benzenemethanol, α,α-dimethyl-2-[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1H-benzimidazol-6-yl]-;JNJ39439335,Inhibitor,capsaicin,JNJ 39439335,TRP Channel,neuropathic pain,calcium ions,Mavatrep,inhibit,Transient receptor potential channels,hTRPV1 channel,HEK293
CBNumber: CB33040790
Molecular Formula: C25H21F3N2O
Formula Weight: 422.45
MOL File: 956274-94-5.mol

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mavatrep Property

Boiling point:: 612.1±65.0 °C(Predicted)
Density: 1.300±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 10.73±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-4591
Product name: Mavatrep
Purity: 99.85%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ApexBio Technology

Product number: B5930
Product name: mavatrep
Packaging: 5mg
Price: $551
Updated: 2021/12/16

ChemScene

Product number: CS-4591
Product name: Mavatrep
Purity: 99.85%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

ApexBio Technology

Product number: B5930
Product name: mavatrep
Packaging: 10mg
Price: $788
Updated: 2021/12/16

ChemScene

Product number: CS-4591
Product name: Mavatrep
Purity: 99.85%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

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mavatrep Chemical Properties,Usage,Production

Biological Activity

mavatrep is a potent and orally bioavailable antagonist of trpv1 with ic50 value of 4.6 nm [1][2].transient receptor potential vanilloid-1 (trpv1) is a thermosensitive and nonselective cation channel, and is a member of the trp channel superfamily. the channel is activated by acidic ph (<6.8), thermal stimuli (>43℃), and endogenous lipidic mediators (anandamide and oxidative metabolites of linoleic acid) [1].mavatrep is a potent and orally bioavailable trpv1 antagonist. in hek293 cells that stably express human or rat trpv1 (rtrpv1) channels, mavatrep (1 μm) inhibited capsaicin-induced ca2+ influx with ic50 values of 4.6 nm and 21 nm. in whole-cell patch clamp electrophysiology assay, mavatrep concentration-dependently inhibited the activation of htrpv1 channels by ph (5.0) and capsaicin (1 μm) with ic50 values of 6.8 and 23 nm, respectively. mavatrep (0.1 μm) also inhibited 74 ± 8.1% heat-evoked currents mediated by htrpv1 [1].in the cfa model of inflammatory of pain, mavatrep (10 mg/kg po) significantly reversed cfa-induced thermal hypersensitivity with ed50 and ed80 values of 1.8 and 7.8 mg/kg, respectively [1].

References

[1]. parsons wh, calvo rr, cheung w, et al. benzo[d]imidazole transient receptor potential vanilloid 1 antagonists for the treatment of pain: discovery of trans-2-(2-{2-[2-(4-trifluoromethyl-phenyl)-vinyl]-1h-benzimidazol-5-yl}-phenyl)-propan-2-ol (mavatrep). j med chem, 2015, 58(9): 3859-3874.

mavatrep Preparation Products And Raw materials

Raw materials

Preparation Products

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956274-94-5, mavatrepRelated Search:

mavatrep

Mavatrep(JNJ-39439335)

JNJ 39439335;JNJ39439335

(trans)-2-(2-{2-[2-(4-trifluoromethylphenyl)vinyl]-1H-benzimidazol-5-yl}phenyl)propan-2-ol

CS-1660

Benzenemethanol, α,α-dimethyl-2-[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1H-benzimidazol-6-yl]-

JNJ39439335,Inhibitor,capsaicin,JNJ 39439335,TRP Channel,neuropathic pain,calcium ions,Mavatrep,inhibit,Transient receptor potential channels,hTRPV1 channel,HEK293

(E)-2-(2-(2-(4-(Trifluoromethyl)styryl)-1H-benzo[d]imidazol-6-yl)phenyl)propan-2-ol

Mavatrep, 10 mM in DMSO

956274-94-5