mavatrep
- Product Name
- mavatrep
- CAS No.
- 956274-94-5
- Chemical Name
- mavatrep
- Synonyms
- CS-1660;mavatrep;Mavatrep(JNJ-39439335);JNJ 39439335;JNJ39439335;(trans)-2-(2-{2-[2-(4-trifluoromethylphenyl)vinyl]-1H-benzimidazol-5-yl}phenyl)propan-2-ol;Benzenemethanol, α,α-dimethyl-2-[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1H-benzimidazol-6-yl]-;JNJ39439335,Inhibitor,capsaicin,JNJ 39439335,TRP Channel,neuropathic pain,calcium ions,Mavatrep,inhibit,Transient receptor potential channels,hTRPV1 channel,HEK293
- CBNumber
- CB33040790
- Molecular Formula
- C25H21F3N2O
- Formula Weight
- 422.45
- MOL File
- 956274-94-5.mol
mavatrep Property
- Boiling point:
- 612.1±65.0 °C(Predicted)
- Density
- 1.300±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 10.73±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- CS-4591
- Product name
- Mavatrep
- Purity
- 99.85%
- Packaging
- 5mg
- Price
- $420
- Updated
- 2021/12/16
- Product number
- B5930
- Product name
- mavatrep
- Packaging
- 5mg
- Price
- $551
- Updated
- 2021/12/16
- Product number
- CS-4591
- Product name
- Mavatrep
- Purity
- 99.85%
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
- Product number
- B5930
- Product name
- mavatrep
- Packaging
- 10mg
- Price
- $788
- Updated
- 2021/12/16
- Product number
- CS-4591
- Product name
- Mavatrep
- Purity
- 99.85%
- Packaging
- 50mg
- Price
- $1800
- Updated
- 2021/12/16
mavatrep Chemical Properties,Usage,Production
Biological Activity
mavatrep is a potent and orally bioavailable antagonist of trpv1 with ic50 value of 4.6 nm [1][2].transient receptor potential vanilloid-1 (trpv1) is a thermosensitive and nonselective cation channel, and is a member of the trp channel superfamily. the channel is activated by acidic ph (<6.8), thermal stimuli (>43℃), and endogenous lipidic mediators (anandamide and oxidative metabolites of linoleic acid) [1].mavatrep is a potent and orally bioavailable trpv1 antagonist. in hek293 cells that stably express human or rat trpv1 (rtrpv1) channels, mavatrep (1 μm) inhibited capsaicin-induced ca2+ influx with ic50 values of 4.6 nm and 21 nm. in whole-cell patch clamp electrophysiology assay, mavatrep concentration-dependently inhibited the activation of htrpv1 channels by ph (5.0) and capsaicin (1 μm) with ic50 values of 6.8 and 23 nm, respectively. mavatrep (0.1 μm) also inhibited 74 ± 8.1% heat-evoked currents mediated by htrpv1 [1].in the cfa model of inflammatory of pain, mavatrep (10 mg/kg po) significantly reversed cfa-induced thermal hypersensitivity with ed50 and ed80 values of 1.8 and 7.8 mg/kg, respectively [1].
References
[1]. parsons wh, calvo rr, cheung w, et al. benzo[d]imidazole transient receptor potential vanilloid 1 antagonists for the treatment of pain: discovery of trans-2-(2-{2-[2-(4-trifluoromethyl-phenyl)-vinyl]-1h-benzimidazol-5-yl}-phenyl)-propan-2-ol (mavatrep). j med chem, 2015, 58(9): 3859-3874.
mavatrep Preparation Products And Raw materials
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