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BHPI

Product Name
BHPI
CAS No.
56632-39-4
Chemical Name
BHPI
Synonyms
BHPI;CS-2134;1,3-Dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-2H-indol-2-one;2H-Indol-2-one, 1,3-dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-
CBNumber
CB33041388
Molecular Formula
C21H17NO3
Formula Weight
331.36
MOL File
56632-39-4.mol
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BHPI Property

Melting point:
272-274 °C
Boiling point:
557.7±50.0 °C(Predicted)
Density 
1.320±0.06 g/cm3(Predicted)
solubility 
DMF: 5 mg/ml; DMSO: 11 mg/ml; Ethanol: 14 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
form 
A crystalline solid
pka
9.43±0.30(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17750
Product name
BHPI
Purity
≥95%
Packaging
500μg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
17750
Product name
BHPI
Purity
≥95%
Packaging
1mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
17750
Product name
BHPI
Purity
≥95%
Packaging
5mg
Price
$412
Updated
2024/03/01
Tocris
Product number
6116
Product name
BHPI
Purity
≥98%(HPLC)
Packaging
50
Price
$745
Updated
2021/12/16
Tocris
Product number
6116
Product name
BHPI
Purity
≥98%(HPLC)
Packaging
10
Price
$177
Updated
2021/12/16
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BHPI Chemical Properties,Usage,Production

Description

BHPI is an antagonist of estrogen receptor α (ERα) that blocks 17β-estradiol-induced proliferation of drug-resistant breast, endometrial, and ovarian cancer cell lines at concentrations ranging from 10 to 1,000 nM. It is effective in vivo, driving tumor regression in mice bearing MCF-7 xenografts at a dose of 15 mg/kg daily. BHPI specifically inhibits ERα-dependent gene expression and protein synthesis by activating the unfolded protein response in cells.

Uses

BHPI is an antagonist of estrogen receptor α (ERα) that blocks 17β-estradiol-induced proliferation of drug-resistant breast, endometrial and ovarian cancer cell lines.

storage

Store at -20°C

BHPI Preparation Products And Raw materials

Raw materials

Preparation Products

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BHPI Suppliers

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56632-39-4, BHPIRelated Search:


  • BHPI
  • 2H-Indol-2-one, 1,3-dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-
  • 1,3-Dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-2H-indol-2-one
  • CS-2134
  • 56632-39-4