Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

Propionimidic acid ethyl ester HYDROCHLORIDE Chemical Properties,Usage,Production

Preparation

To a 250-ml round-bottomed, three-necked flask equipped with mechan­ical stirrer, dropping funnel, and condenser with a top outlet tube extend­ing into a saturated barium hydroxide solution is added 7.3 gm (0.10 mole) of propionamide. The flask is placed in a water bath at 40-45°C while 10.9 gm (0.10 mole) of ethyl chloroformate is added rapidly from the dropping funnel. The reaction mixture is rapidly stirred and in 15 min the reaction commences with the evolution of C02 as evidenced by precipita­tion in the Ba(OH)2 solution. After the carbon dioxide ceases to be evolved the product is washed with anhydrous ether and dried in a vacuum desiccator over cone, sulfuric acid to afford 8.9 gm (65%), m.p. 92-93°C.

The reaction of ethyl chloroformate with N-methyl or N-ethyl alkyla-mides afforded the corresponding N-alkyl imidate hydrochloride, a class of compounds for which no other direct method of synthesis exists. The reaction fails with acetanilide, n-butylacetamide, N-methyl-acetamide, and N-methylcaprylamide. However, thiobenzamide and thio-acetanilide each react with ethyl chloroformate to give ethyl benzimidate hydrochloride and ethyl N-phenylacetaimidate hydrochloride, respectively.