ChemicalBook > CAS DataBase List > SPDB

SPDB

Product Name: SPDB
CAS No.: 115088-06-7
Chemical Name: SPDB
Synonyms: LKB;SPDB;C4-SPDB;SPDB crosslinker;SPDB, 10 mM in DMSO;N-Succinimidyl-4-(2-pyridyldithio)butanoate;5-dioxopyrrolidin-1-yl 4-(pyridin-2-yldisulfanyl)butanoate;2,5-dioxopyrrolidin-1-yl 4-(pyridin-2-yldisulfanyl)butanoate;4-(Pyridin-2-yldisulfanyl)butyric acid N-Hydroxysuccinimide ester;inhibit,SPDB,Antibody-drug conjugates linkers,ADC Linkers,Inhibitor
CBNumber: CB33044051
Molecular Formula: C13H14N2O4S2
Formula Weight: 326.39
MOL File: 115088-06-7.mol

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SPDB Property

Melting point:: 47-48 °C
Boiling point:: 480.1±55.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Ethanol:100.0(Max Conc. mg/mL);306.39(Max Conc. mM)
pka: 1.89±0.19(Predicted)
form: <47°C Solid,>48°C Liquid
color: Off-white to light yellow

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Safety

HS Code: 29251900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5677
Product name: SPDB
Purity: 99.30%
Packaging: 10mg
Price: $144
Updated: 2021/12/16

ChemScene

Product number: CS-5677
Product name: SPDB
Purity: 99.30%
Packaging: 5mg
Price: $108
Updated: 2021/12/16

ChemScene

Product number: CS-5677
Product name: SPDB
Purity: 99.30%
Packaging: 50mg
Price: $336
Updated: 2021/12/16

ChemScene

Product number: CS-5677
Product name: SPDB
Purity: 99.30%
Packaging: 100mg
Price: $456
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611870
Product name: SPDB
Purity: >98%
Packaging: 100mg
Price: $510
Updated: 2021/12/16

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SPDB Chemical Properties,Usage,Production

Uses

SPDB is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs)[1].

IC 50

Disulfide Cleavable Linker; Cleavable Linker

References

[1] Widdison WC et al. Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolitesin Cancer Cells andInduce High Levels of Bystander Killing. Bioconjug Chem, 2015 Nov 18, 26(11):2261-78. DOI:10.1021/acs.bioconjchem.5b00430

SPDB Preparation Products And Raw materials

Raw materials

Preparation Products

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115088-06-7, SPDBRelated Search:

SPDB

2,5-dioxopyrrolidin-1-yl 4-(pyridin-2-yldisulfanyl)butanoate

SPDB crosslinker

5-dioxopyrrolidin-1-yl 4-(pyridin-2-yldisulfanyl)butanoate

4-(Pyridin-2-yldisulfanyl)butyric acid N-Hydroxysuccinimide ester

LKB

N-Succinimidyl-4-(2-pyridyldithio)butanoate

Butanoic acid, 4-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester

inhibit,SPDB,Antibody-drug conjugates linkers,ADC Linkers,Inhibitor

C4-SPDB

SPDB, 10 mM in DMSO

115088-06-7