THS-044

Product Name: THS-044
CAS No.: 62054-67-5
Chemical Name: THS-044
Synonyms: THS-044;THS044;THS 044;N-(2-Nitro-4-(trifluoromethyl)phenyl)morpholin-4-amine;4-Morpholinamine, N-[2-nitro-4-(trifluoromethyl)phenyl]-
CBNumber: CB33053941
Molecular Formula: C11H12F3N3O3
Formula Weight: 291.23
MOL File: 62054-67-5.mol

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THS-044 Property

Melting point:: 106-108 °C
Boiling point:: 347.1±52.0 °C(Predicted)
Density: 1.464±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: -0.19±0.50(Predicted)
color: Yellow to orange

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5318
Product name: THS-044
Purity: 99.67%
Packaging: 1mg
Price: $200
Updated: 2021/12/16

ChemScene

Product number: CS-5318
Product name: THS-044
Purity: 99.67%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-5318
Product name: THS-044
Purity: 99.67%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611877
Product name: THS-044
Purity: >98%
Packaging: 10mg
Price: $615.4
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611877
Product name: THS-044
Purity: >98%
Packaging: 50mg
Price: $2157.3
Updated: 2021/12/16

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THS-044 Chemical Properties,Usage,Production

Uses

THS-044 binding stabilizes the HIF2α PAS-B folded state, for regulating HIF2 activity in endogenous and clinical settings. Target: HIF2α Limited trypsin proteolysis reveals that both apo and THS-044-bound protein are efficiently cut at R330 in the extended HI loop. In the THS-044 bound state, there appears no additional proteolysis at the remaining candidate trypsin sites. In contrast, these THS-044-protected sites are protease accessible in the unliganded protein, leading its complete degradation. In parallel, NMR-based deuterium exchange measurements revealed a dramatic stabilization of the THS-044-bound protein β-sheet, with some sites experiencing 100-fold enhanced protection factors relative to the ligand-free protein.

References

[1] Motto I, et al. New aryl hydrocarbon receptor homology model targeted to improve docking reliability. J Chem Inf Model. 2011 Nov 28;51(11):2868-2881. DOI:10.1021/ci2001617
[2] Scheuermann TH, et al. Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):450-455. DOI:10.1073/pnas.0808092106

THS-044 Preparation Products And Raw materials

Raw materials

Preparation Products

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THS-044 Suppliers

China 33 United States 4 Global 37

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4827
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 9697
Advantage: 55

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9532
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

MQ (shanghai) Pharmaceuticals Co., Ltd.

Tel: 13761635123
Fax: 1014988033@qq
Email: sales@linyuepharm.com
Country: China
ProdList: 5562
Advantage: 55

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 1788
Advantage: 58

Tianjin Kaifu Pharmaceutical Technology Co., Ltd.

Tel: 18081075745
Email: chemflowtech@sina.com
Country: China
ProdList: 1886
Advantage: 58

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View Lastest Price from THS-044 manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 1-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]HEXAMETHYLENIMINE 62054-67-5
Price: US $0.10/KG
Min. Order: 0.1KG
Purity: 98%HPLC
Supply Ability: 200tons
Release date: 2025-08-15

Shaanxi Dideu Medichem Co. Ltd

Product: THS-044 62054-67-5
Price: US $0.10/KG
Min. Order: 0.1KG
Purity: 98%HPLC
Supply Ability: 200tons
Release date: 2025-08-15

62054-67-5, THS-044Related Search:

THS044;THS 044

THS-044

4-Morpholinamine, N-[2-nitro-4-(trifluoromethyl)phenyl]-

N-(2-Nitro-4-(trifluoromethyl)phenyl)morpholin-4-amine

62054-67-5