ChemicalBook > CAS DataBase List > Methylamino-PEG4-acid
Methylamino-PEG4-acid
- Product Name
- Methylamino-PEG4-acid
- CAS No.
- 1283658-71-8
- Chemical Name
- Methylamino-PEG4-acid
- Synonyms
- CAS_1283658-71-8;Methylamino-PEG4-acid;Methylamino-PEG4-CH2CH2COOH;Methylamino-PEG4-acid HCl salt;Methylamino-PEG4-acid hydrochloride;4,7,10,13-Tetraoxa-16-azaheptadecanoic acid;5,8,11,14-Tetraoxa-2-azaheptadecan-17-oic Acid
- CBNumber
- CB33054281
- Molecular Formula
- C12H25NO6
- Formula Weight
- 279.33
- MOL File
- 1283658-71-8.mol
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Methylamino-PEG4-acid Property
- Boiling point:
- 405.5±40.0 °C(Predicted)
- Density
- 1.093±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, protect from light
- solubility
- Soluble in Water, DMSO
- pka
- 4.28±0.10(Predicted)
- form
- Viscous Liquid
- color
- Colorless to light yellow
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N-Bromosuccinimide Price
TRC
- Product number
- M563190
- Product name
- Methylamino-PEG4-acid
- Packaging
- 2.5mg
- Price
- $45
- Updated
- 2021/12/16
TRC
- Product number
- M563190
- Product name
- Methylamino-PEG4-acid
- Packaging
- 5mg
- Price
- $65
- Updated
- 2021/12/16
BroadPharm
- Product number
- BP-22202
- Product name
- Methylamino-PEG4-acidHClsalt
- Purity
- 98%
- Packaging
- 100mg
- Price
- $320
- Updated
- 2021/12/16
BroadPharm
- Product number
- BP-22202
- Product name
- Methylamino-PEG4-acidHClsalt
- Purity
- 98%
- Packaging
- 250mg
- Price
- $540
- Updated
- 2021/12/16
Apolloscientific
- Product number
- BIPG1537
- Product name
- Methylamino-PEG4-acid
- Packaging
- 100mg
- Price
- $623
- Updated
- 2021/12/16
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Methylamino-PEG4-acid Chemical Properties,Usage,Production
Description
Methylamino-PEG4-acid HCl salt is a PEG linker containing a carboxylic acid with a methylamine group. The hydrophilic PEG spacer increases solubility in aqueous media. The methylamine group is reactive with carboxylic acids, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Uses
Methylamino-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Methylamino-PEG4-acid Preparation Products And Raw materials
Raw materials
Preparation Products
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