JNJ26854165(Quisinostat) 2HCl

Product Name: JNJ26854165(Quisinostat) 2HCl
CAS No.: 875320-31-3
Chemical Name: JNJ26854165(Quisinostat) 2HCl
Synonyms: Quisinostat 2HCl;JNJ26854165 2HCL;JNJ-26481585-AAC;JNJ-26481585 2HCl;Quisinostat dihydrochloride;JNJ-26481585 (hydrochloride);JNJ 26481585 dihydrochloride;JNJ26854165(Quisinostat) 2HCl;Quisinostat dihydrochloride, 10 mM in DMSO;Quisinostat (JNJ-26481585) dihydrochloride
CBNumber: CB33054559
Molecular Formula: C21H27ClN6O2
Formula Weight: 430.94
MOL File: 875320-31-3.mol

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JNJ26854165(Quisinostat) 2HCl Property

solubility: DMSO:46.7(Max Conc. mg/mL);99.9(Max Conc. mM)
form: A crystalline solid
color: White to yellow

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Safety

HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 14088
Product name: JNJ-26481585 (hydrochloride)
Purity: ≥98%
Packaging: 1 mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 14088
Product name: JNJ-26481585 (hydrochloride)
Purity: ≥98%
Packaging: 5 mg
Price: $199
Updated: 2024/03/01

Cayman Chemical

Product number: 14088
Product name: JNJ-26481585 (hydrochloride)
Purity: ≥98%
Packaging: 10 mg
Price: $356
Updated: 2024/03/01

Cayman Chemical

Product number: 14088
Product name: JNJ-26481585 (hydrochloride)
Purity: ≥98%
Packaging: 50 mg
Price: $790
Updated: 2024/03/01

Axon Medchem

Product number: Axon2529
Product name: JNJ26481585dihydrochloride-Quisinostatdihydrochloride
Purity: 99%
Packaging: 2x5mg
Price: $198
Updated: 2021/12/16

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JNJ26854165(Quisinostat) 2HCl Chemical Properties,Usage,Production

Uses

Quisinostat dihydrochloride (JNJ-26481585 dihydrochloride) is an orally available, potent pan-HDAC inhibitor with IC50s of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM, and 0.37 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11, respectively. Quisinostat dihydrochloride has a broad spectrum antitumoral activity[1].

in vivo

JNJ-26481585 (40 mg/kg; p.o.; once daily, for 3 days) as a potent HDAC1 inhibitor p21waf1,cip1 ZsGreen tumors in vivo^[1].
JNJ-26481585 induces continuous H3 acetylation in tumor tissue in vivo^[1].
JNJ-26481585 (10 mg/kg; once daily; i.p.; for 14 days) strongly inhibits the growth of large pre-established HCT116 colon xenografts^[1].

Animal Model:	NMRI nude mice, with HCT116 colon carcinoma cells xenografts^[1]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection, once daily, for 14 days
Result:	Strongly inhibited the growth of large pre-established HCT116 colon xenografts.

IC 50

HDAC1: 0.11 nM (IC₅₀); HDAC2: 0.33 nM (IC₅₀); HDAC3: 4.86 nM (IC₅₀); HDAC4: 0.64 nM (IC₅₀); HDAC5: 3.69 nM (IC₅₀); HDAC6: 76.8 nM (IC₅₀); HDAC7: 119 nM (IC₅₀); HDAC8: 4.26 nM (IC₅₀); HDAC9: 32.1 nM (IC₅₀); HDAC10: 0.46 nM (IC₅₀); HDAC11: 0.37 nM (IC₅₀)

References

[1] Arts J, et al. JNJ-26481585, a novel "second-generation" oral histone deacetylase inhibitor, shows broad-spectrum preclinical antitumoral activity. Clin Cancer Res. 2009 Nov 15;15(22):6841-51. DOI:10.1158/1078-0432.CCR-09-0547

JNJ26854165(Quisinostat) 2HCl Preparation Products And Raw materials

Raw materials

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JNJ26854165(Quisinostat) 2HCl Suppliers

China 67 India 1 United States 4 USA 1 Global 73

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