Benzyl-PEG2-CH2CO2tBu

Product Name: Benzyl-PEG2-CH2CO2tBu
CAS No.: 1309451-06-6
Chemical Name: Benzyl-PEG2-CH2CO2tBu
Synonyms: tert-butyl 2-(2-(benzyloxy)ethoxy)acetate;BnO-PEG1-CH2CO2tBu;Benzyl-PEG2-CH2CO2tBu;Bromoacetamido-PEG3-amine-Boc;tert-butyl 2-(2-(benzyloxy)ethoxy)acetate(WXPC0080);Acetic acid, 2-[2-(phenylmethoxy)ethoxy]-, 1,1-dimethylethyl ester
CBNumber: CB33062376
Molecular Formula: C15H22O4
Formula Weight: 266.33
MOL File: 1309451-06-6.mol

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Benzyl-PEG2-CH2CO2tBu Property

Boiling point:: 354.2±22.0 °C(Predicted)
Density: 1.048±0.06 g/cm3(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B289365
Product name: Benzyl-Peg2-Ch2co2tbu
Packaging: 50mg
Price: $175
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1190
Product name: Benzyl-PEG2-CH2CO2tBu
Packaging: 500mg
Price: $740
Updated: 2021/12/16

BroadPharm

Product number: BP-22150
Product name: Benzyl-PEG2-CH2CO2tBu
Purity: 98%
Packaging: 2g
Price: $840
Updated: 2021/12/16

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Benzyl-PEG2-CH2CO2tBu Chemical Properties,Usage,Production

Description

Benzyl-PEG2-CH2CO2tBu is a PEG linker containing a benzyl group and a t-butyl protected carbonyl. Both the benzyl and t-Butyl group can be removed under acidic conditions. The carboxylic acid can be reacted with primary amines in the presence of activators such as EDC and DCC to form stable amide bonds. The hydrophilic PEG linkers increase the water solubility of the compound in aqueous media.

Uses

BnO-PEG1-CH2CO2tBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Benzyl-PEG2-CH2CO2tBu Preparation Products And Raw materials

Raw materials

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Benzyl-PEG2-CH2CO2tBu Suppliers

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1309451-06-6, Benzyl-PEG2-CH2CO2tBuRelated Search:

Benzyl-PEG2-CH2CO2tBu

tert-butyl 2-(2-(benzyloxy)ethoxy)acetate(WXPC0080)

tert-butyl 2-(2-(benzyloxy)ethoxy)acetate

BnO-PEG1-CH2CO2tBu

Acetic acid, 2-[2-(phenylmethoxy)ethoxy]-, 1,1-dimethylethyl ester

Bromoacetamido-PEG3-amine-Boc

1309451-06-6