ChemicalBook > CAS DataBase List > Bis-Propargyl-PEG13
Bis-Propargyl-PEG13
- Product Name
- Bis-Propargyl-PEG13
- CAS No.
- 1351373-50-6
- Chemical Name
- Bis-Propargyl-PEG13
- Synonyms
- CAS_1351373-50-6;Bis-propargyl-PEG12;Bis-Propargyl-PEG13;Propargyl-PEG12-Propargyl;4,7,10,13,16,19,22,25,28,31,34,37,40-Tridecaoxatritetraconta-1,42-diyne;Bis-propargyl-PEG12/4,7,10,13,16,19,22,25,28,31,34,37,40-Tridecaoxatritetraconta-1,42-diyne
- CBNumber
- CB33062422
- Molecular Formula
- C30H54O13
- Formula Weight
- 622.74
- MOL File
- 1351373-50-6.mol
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Bis-Propargyl-PEG13 Property
- solubility
- Soluble in Water, DMSO, DMF, DCM
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N-Bromosuccinimide Price
TRC
- Product number
- B523918
- Product name
- Bis-propargyl-PEG13
- Packaging
- 5mg
- Price
- $45
- Updated
- 2021/12/16
BroadPharm
- Product number
- BP-22514
- Product name
- Bis-propargyl-PEG13
- Purity
- 98%
- Packaging
- 250mg
- Price
- $350
- Updated
- 2021/12/16
Activate Scientific
- Product number
- AS107811
- Product name
- Bis-propargyl-PEG12
- Purity
- 97%
- Packaging
- 250mg
- Price
- $435
- Updated
- 2021/12/16
BroadPharm
- Product number
- BP-22514
- Product name
- Bis-propargyl-PEG13
- Purity
- 98%
- Packaging
- 500mg
- Price
- $540
- Updated
- 2021/12/16
Apolloscientific
- Product number
- BIPG1305
- Product name
- Bis-Propargyl-PEG13
- Packaging
- 250mg
- Price
- $681
- Updated
- 2021/12/16
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Bis-Propargyl-PEG13 Chemical Properties,Usage,Production
Description
Bis-propargyl-PEG13 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Uses
Bis-propargyl-PEG12 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bis-propargyl-PEG12 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
IC 50
PEGs
structure and hydrogen bonding
Bis-propargyl-PEG13 comprises two propargyl groups which can form triazole linkages with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry reactions. The hydrophilic PEG units help improve the solubility of the molecule in aqueous media.
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Bis-Propargyl-PEG13 Preparation Products And Raw materials
Raw materials
Preparation Products
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