ChemicalBook > CAS DataBase List > Cbz-N-amido-PEG8-acid

Cbz-N-amido-PEG8-acid

Product Name
Cbz-N-amido-PEG8-acid
CAS No.
1334177-87-5
Chemical Name
Cbz-N-amido-PEG8-acid
Synonyms
CBZ-NH-PEG8-COOH;CBZ-NH-PEG8-acid;CbzNH-PEG8-C2-COOH;Cbz-NH-PEG8-C2-acid;Cbz-N-amido-PEG8-acid;CBZ-N-AMIDO-PEG8-COOH;CBZ-NH-PEG8-CH2CH2COOH;CBZ-NH-PEG8-propionic acid;CBZ-N-amido-dPEG??-acid (QBD-10276);1-(Benzyl) 5,8,11,14,17,20,23,26-octaoxa-2-azanonacosanedioate
CBNumber
CB33062462
Molecular Formula
C27H45NO12
Formula Weight
575.65
MOL File
1334177-87-5.mol
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Cbz-N-amido-PEG8-acid Property

Boiling point:
681.2±55.0 °C(Predicted)
Density 
1.165±0.06 g/cm3(Predicted)
storage temp. 
Storage temp. 2-8°C
solubility 
Soluble in Water, DMSO, DCM, DMF
pka
4.28±0.10(Predicted)
form 
Liquid
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
C227215
Product name
Cbz-NH-PEG8-CH2CH2COOH
Packaging
100mg
Price
$175
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
POL0002313
Product name
Z-NH-DPEG-(8)-COOH
Purity
95.00%
Packaging
100MG
Price
$302.4
Updated
2021/12/16
Iris Biotech GmbH
Product number
PEG1800
Product name
Z-NH-dPEG(8)-COOH
Packaging
100mg
Price
$351
Updated
2021/12/16
dPEG
Product number
10276
Product name
CBZ-N-amido-dPEG®₈-acid
Packaging
1000mg
Price
$600
Updated
2021/12/16
BroadPharm
Product number
BP-21647
Product name
Cbz-N-amido-PEG8-acid
Purity
98%
Packaging
2g
Price
$720
Updated
2021/12/16
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Cbz-N-amido-PEG8-acid Chemical Properties,Usage,Production

Description

Cbz-N-amido-PEG8-acid is a PEG linker containing a CBZ-protected amino group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The protected amine can be deprotected by acidic conditions.

Uses

Cbz-NH-PEG8-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Cbz-N-amido-PEG8-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Cbz-N-amido-PEG8-acid manufacturers

LAURENT
Product
CBZ-NH-PEG8-CH2CH2COOH 1334177-87-5
Price
US $510.00/g
Min. Order
1g
Purity
98%
Supply Ability
300kg
Release date
2025-11-19
XIAMEN SINOPEG BIOTECH CO., LTD.
Product
3-oxo-1-phenyl-2,7,10,13,16,19,22,25,28-nonaoxa-4-azahentriacontan-31-oic acid 1334177-87-5
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%
Supply Ability
1g/bottle, 10g/bottle, 100g/bottle
Release date
2025-09-12

1334177-87-5, Cbz-N-amido-PEG8-acidRelated Search:

CbzNH-PEG4-CH2COOH Z-15-aMino-4,7,10,13-tetraoxapentadecacanoic acid Cbz-N-amido-PEG2-acid Z-9-aMino-4,7-dioxanonanoic acid Cbz-N-amido-PEG6-acid Cbz-N-amido-PEG3-acid Cbz-N-amido-PEG5-acid

  • Cbz-N-amido-PEG8-acid
  • CBZ-NH-PEG8-propionic acid
  • CBZ-NH-PEG8-CH2CH2COOH
  • CBZ-N-AMIDO-PEG8-COOH
  • CBZ-NH-PEG8-COOH
  • Cbz-NH-PEG8-C2-acid
  • 5,8,11,14,17,20,23,26-Octaoxa-2-azanonacosanedioic acid, 1-(phenylmethyl) ester
  • 3-Oxo-1-phenyl-2,7,10,13,16,19,22,25,28-nonaoxa-4-azahentriacontan-31-oic acid
  • CBZ-NH-PEG8-acid
  • 1-(Phenylmethyl) 5,8,11,14,17,20,23,26-octaoxa-2-azanonacosanedioate
  • CbzNH-PEG8-CH2CH2COOH/5,8,11,14,17,20,23,26-Octaoxa-2-azanonacosanedioic acid, 1-(phenylmethyl) ester
  • CbzNH-PEG8-C2-COOH
  • 1-(Benzyl) 5,8,11,14,17,20,23,26-octaoxa-2-azanonacosanedioate
  • 3-[2-[2-[2-[2-[2-[2-[2-[2-(benzyloxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
  • CBZ-N-amido-dPEG??-acid (QBD-10276)
  • 1334177-87-5
  • C27H45NO12