2-D08
- Product Name
- 2-D08
- CAS No.
- 144707-18-6
- Chemical Name
- 2-D08
- Synonyms
- 2-D08;2-D08 >=98% (HPLC);2',3',4'-Trihydroxyflavone;4H-1-Benzopyran-4-one, 2-(2,3,4-trihydroxyphenyl)-;2-D08/2-(2,3,4-Trihydroxyphenyl)-4H-1-benzopyran-4-one;Ubiquitin ligase,Axl,2-D08,Tyro3,E3 ligating enzyme,Ubiquitin activating enzyme,Inhibitor,E1 activating enzyme,inhibit,2-D-08,2 D08,E1/E2/E3 Enzyme,2D08,E2 conjugating enzyme,Mer,Ubiquitin conjugating enzyme,TAM Receptor
- CBNumber
- CB33067528
- Molecular Formula
- C15H10O5
- Formula Weight
- 270.24
- MOL File
- 144707-18-6.mol
2-D08 Property
- Boiling point:
- 517.9±50.0 °C(Predicted)
- Density
- 1.548±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- ≥74.6 mg/mL in DMSO; ≥1.76 mg/mL in EtOH with gentle warming and ultrasonic; insoluble in H2O
- form
- powder
- pka
- 7.45±0.40(Predicted)
- color
- white to beige
Safety
- WGK Germany
- 3
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1052
- Product name
- 2-D08
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $115
- Updated
- 2023/06/20
- Product number
- SML1052
- Product name
- 2-D08
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $464
- Updated
- 2023/06/20
- Product number
- 20459
- Product name
- 2-D08
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 20459
- Product name
- 2-D08
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 20459
- Product name
- 2-D08
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $139
- Updated
- 2024/03/01
2-D08 Chemical Properties,Usage,Production
Uses
2-D08 has been used as a small ubiquitin-like modifier (SUMO)ylation inhibitor.
Biological Activity
2-d08 (2’,3’,4’-trihydroxyflavone) is a sumoylation inhibitor.protein sumoylation is a dynamic posttranslational modification involved in various biological processes, such as cellular homeostasis and development. sumoylation has been reported to play a key role in cancer, though so far there are few small molecule probes available.
Biochem/physiol Actions
2-D08 is a potent and cell-permeable inhibitor of sumoylation that block the transfer of SUMO (small ubiquitin-like modifier) from the E2 enzyme (Ubc9) thioester conjugate to the substrate.
in vitro
2-d08 was identified as a cell permeable, mechanistically unique inhibitor of protein sumoylation. this compound was found to be able to block sumoylation of topoisomerase i in two different cancer cell lines when co-dosed with camptothecin. in addition, futher analyses indicated that 2-d08 inhibited sumoylation via preventing transfer of small ubiquitin-like modifier (sumo) from the ubc9-sumo thioester to the substrate without affecting sumo-activating enzyme e1 (sae-1/2) or e2 ubc9-sumo thioester formation, a mechanism of action that was unprecedented before [1]. moreover, it was found that 2-d08 at 100 μm could effectively inhibit 10 μm camptothecin induced topoisomerase i sumoylation in breast cancer without affecting overall cellular protein ubiquitinations [2].
References
[1] kim ys, keyser sg, schneekloth js jr. synthesis of 2',3',4'-trihydroxyflavone (2-d08), an inhibitor of protein sumoylation. bioorg med chem lett. 2014 feb 15;24(4):1094-7.
[2] kim ys, nagy k, keyser s, schneekloth js jr. an electrophoretic mobility shift assay identifies a mechanistically unique inhibitor of protein sumoylation. chem biol. 2013 apr 18;20(4):604-13.
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View Lastest Price from 2-D08 manufacturers
- Product
- 2-D08 144707-18-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%HPLC
- Supply Ability
- 10t
- Release date
- 2019-12-24