9H-Pyrido[3,4-b]indole-1-carboxylic acid
- Product Name
- 9H-Pyrido[3,4-b]indole-1-carboxylic acid
- CAS No.
- 26052-96-0
- Chemical Name
- 9H-Pyrido[3,4-b]indole-1-carboxylic acid
- Synonyms
- β-Carboline-1-carboxylic Acid;??-Carboline-1-carboxylic acid;Carboline 1-carboxylic acid, β-;9H-pyrido[3,4-b]indol-1-carboxylic acid;9H-Pyrido[3,4-b]indole-1-carboxylic acid
- CBNumber
- CB33076827
- Molecular Formula
- C12H8N2O2
- Formula Weight
- 212.2
- MOL File
- 26052-96-0.mol
9H-Pyrido[3,4-b]indole-1-carboxylic acid Property
- Boiling point:
- 538.7±30.0 °C(Predicted)
- Density
- 1.497±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble; Methanol: soluble
- form
- A solid
- pka
- 0.83±0.30(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B530605
- Product name
- 9H-pyrido[3,4-b]indole-1-carboxylicAcid
- Packaging
- 100mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- 9928CV
- Product name
- 9H-Pyrido[3,4-b]indole-1-carboxylicacid
- Packaging
- 100mg
- Price
- $328
- Updated
- 2021/12/16
- Product number
- P5040
- Product name
- 9H-Pyrido[3,4-b]indole-1-carboxylicacid
- Purity
- 97.00%
- Packaging
- 1G
- Price
- $2280
- Updated
- 2021/12/16
- Product number
- P5040
- Product name
- 9H-Pyrido[3,4-b]indole-1-carboxylicacid
- Purity
- 97.00%
- Packaging
- 5G
- Price
- $3900
- Updated
- 2021/12/16
- Product number
- P5040
- Product name
- 9H-Pyrido[3,4-b]indole-1-carboxylicacid
- Purity
- 97.00%
- Packaging
- 25G
- Price
- $7320
- Updated
- 2021/12/16
9H-Pyrido[3,4-b]indole-1-carboxylic acid Chemical Properties,Usage,Production
Uses
β-Carboline 1-carboxylic acid is a β-carboline alkaloid with anti-inflammatory, antifibrotic, antitumor and antibacterial activities. β-Carboline 1-carboxylic acid is the cAMP phosphodiesterase (IC50: 96 μM) and indoleamine 2, 3-dioxygenase (IDO) inhibitor. β-Carboline 1-carboxylic acid is cytotoxic to tumor cells. β-Carboline 1-carboxylic acid inhibits inflammation through the NF-κb/p65 pathway and can reverse epithelial-mesenchymal transition (EMT). In addition, β-Carboline 1-carboxylic acid has strong inhibitory activity against S. aureus (IC50: 47.70 μg/mL) and E. coli (IC50: 19.17 μg/mL)[1][2][3][4].
Biological Activity
β-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities.1,2,3 It reduces LPS-induced increases in MCP-1, TNF-α, IL-6, and IL-1β levels in RAW 264.7 cells when used at a concentration of 15 μg/ml and inhibits the epithelial-to-mesenchymal transition (EMT) induced by TGF-β1 in A549 cells.2 β-Carboline-1-carboxylic acid induces cytotoxicity in CT26.WT, K562, and SGC-7901 cells (IC50s = 14.96, 22.11, and 19.7 μg/ml, respectively) but not HepG2 or A549 cells (IC50s = 36.41 and 41.51 μg/ml, respectively).1 It also inhibits cAMP phosphodiesterase with an IC50 value of 96 μM.3
References
1.Lai, Z.-Q., Liu, W.-H., Ip, S.-P., et al.Seven alkaloids from Picrasma quassioides and their cytotoxic activitiesChem. Nat. Compd.50(5)884-888(2014) 2.Cui, Y., Jiang, L., Yu, R., et al.β-carboline alkaloids attenuate bleomycin induced pulmonary fibrosis in mice through inhibiting NF-kb/p65 phosphorylation and epithelial-mesenchymal transitionJ. Ethnopharmacol.243112096(2019) 3.Sung, Y.-I., Koike, K., Nikaido, T., et al.Inhibitors of cyclic AMP phosphodiesterase in Picrasma quassioides BENNET, and inhibitory activities of related β-carboline alkaloidsChem. Pharm. Bull. (Tokyo)32(5)1872-1877(1984)
9H-Pyrido[3,4-b]indole-1-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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