4-cyclopropyl-2-methylbenzoic acid
- Product Name
- 4-cyclopropyl-2-methylbenzoic acid
- CAS No.
- 909698-10-8
- Chemical Name
- 4-cyclopropyl-2-methylbenzoic acid
- Synonyms
- 4-cyclopropyl-2-methylbenzoic acid;Benzoic acid, 4-cyclopropyl-2-methyl-
- CBNumber
- CB33084619
- Molecular Formula
- C11H12O2
- Formula Weight
- 176.21
- MOL File
- 909698-10-8.mol
4-cyclopropyl-2-methylbenzoic acid Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Light yellow to yellow Solid
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 2589DP
- Product name
- 4-Cyclopropyl-2-methylbenzoicacid
- Packaging
- 250mg
- Price
- $107
- Updated
- 2021/12/16
- Product number
- 909698108
- Product name
- 4-Cyclopropyl-2-methylbenzoicacid
- Packaging
- 1g
- Price
- $169.35
- Updated
- 2021/12/16
- Product number
- CM255713
- Product name
- 4-Cyclopropyl-2-methylbenzoicacid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $192
- Updated
- 2021/12/16
- Product number
- CD12009587
- Product name
- 4-Cyclopropyl-2-methylbenzoicacid
- Purity
- 98%
- Packaging
- 1g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- 29284
- Product name
- 4-Cyclopropyl-2-methylbenzoicacid
- Purity
- 97%
- Packaging
- 25g
- Price
- $2605
- Updated
- 2021/12/16
4-cyclopropyl-2-methylbenzoic acid Chemical Properties,Usage,Production
Synthesis
909698-09-5
909698-10-8
To a stirred mixed solution of methyl 4-cyclopropyl-2-methylbenzoate (1.3 g, 6.84 mmol) in tetrahydrofuran (THF, 9 mL), methanol (MeOH, 6 mL) and water (3 mL) was added lithium hydroxide monohydrate (0.842 g, 20.52 mmol). The reaction mixture was stirred at 70 °C for 2 hours. After completion of the reaction, excess solvent was removed by distillation under reduced pressure. The residue was dissolved in water and acidified to pH < 7 with 10% hydrochloric acid (HCl) solution, followed by three extractions with ethyl acetate (EtOAc). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the target product 4-cyclopropyl-2-methylbenzoic acid (1.2 g, 99% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 7.52 (d, J = 7.6 Hz, 1H), 6.75-6.74 (m, 2H), 1.84-1.81 (m, 1H), 0.92-0.87 (m, 2H), 0.64-0.60 (m, 2H).
References
[1] Patent: WO2014/125408, 2014, A2. Location in patent: Page/Page column 24
[2] Patent: US2006/205773, 2006, A1. Location in patent: Page/Page column 22
[3] Patent: US2010/222325, 2010, A1. Location in patent: Page/Page column 118
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 1, p. 512 - 516
4-cyclopropyl-2-methylbenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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