1,1-DIMETHOXY-4-DIMETHYLAMINOBUT-3-EN-2-ONE
- Product Name
- 1,1-DIMETHOXY-4-DIMETHYLAMINOBUT-3-EN-2-ONE
- CAS No.
- 67751-23-9
- Chemical Name
- 1,1-DIMETHOXY-4-DIMETHYLAMINOBUT-3-EN-2-ONE
- Synonyms
- BUTTPARK 43\57-38;1,1-Dimethoxy-4-dimethylamino-3-buten-2-one;1,1-DIMETHOXY-4-DIMETHYLAMINOBUT-3-EN-2-ONE;4-Dimethylamino-1,1-dimethoxy-3-butene-2-one;1,1-DiMethoxyI-4-diMethylaMinobut-3-en-2-one;E-1,1-Dimethoxy-4-dimethylaminobut-3-en-2-one;4-(DIMETHYLAMINO)-1,1-DIMETHOXYBUT-3-EN-2-ONE;4-(Dimethylamino)-1,1-dimethoxy-3-buten-2-one;3-Buten-2-one, 4-(dimethylamino)-1,1-dimethoxy-;4- (dimethylamine) -1,1 dimethoxybut-3 en 2-one
- CBNumber
- CB3309001
- Molecular Formula
- C8H15NO3
- Formula Weight
- 173.21
- MOL File
- 67751-23-9.mol
1,1-DIMETHOXY-4-DIMETHYLAMINOBUT-3-EN-2-ONE Property
- Boiling point:
- 110 °C
- Density
- 1.008g/ml
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 6.42±0.70(Predicted)
- form
- liquid
- color
- Dark brown
- InChI
- InChI=1S/C8H15NO3/c1-9(2)6-5-7(10)8(11-3)12-4/h5-6,8H,1-4H3
- InChIKey
- DFZIBCAWOSFLFR-UHFFFAOYSA-N
- SMILES
- C(OC)(OC)C(=O)C=CN(C)C
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 2914120000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D471075
- Product name
- 4-Dimethylamino-1,1-dimethoxybut-3-en-2-one
- Packaging
- 50g
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- CHM0017054
- Product name
- 1,1-DIMETHOXY-4-DIMETHYLAMINOBUT-3-EN-2-ONE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $983.88
- Updated
- 2021/12/16
- Product number
- CHM0017054
- Product name
- 1,1-DIMETHOXY-4-DIMETHYLAMINOBUT-3-EN-2-ONE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1168.42
- Updated
- 2021/12/16
- Product number
- OR27385
- Product name
- 4-(dimethylamino)-1,1-dimethoxybut-3-en-2-one
- Purity
- 98%
- Packaging
- 5g
- Price
- $166
- Updated
- 2021/12/16
- Product number
- 017202
- Product name
- 1,1-Dimethoxy-4-dimethylaminobut-3-en-2-one
- Purity
- 95%
- Packaging
- 100g
- Price
- $630
- Updated
- 2021/12/16
1,1-DIMETHOXY-4-DIMETHYLAMINOBUT-3-EN-2-ONE Chemical Properties,Usage,Production
Uses
4-Dimethylamino-1,1-dimethoxybut-3-en-2-one is used in the preparation of substituted anthranilic amide derivatives as VEGF modulators against cancer and other disorders.
Synthesis
6342-56-9
4637-24-5
67751-23-9
The general procedure for the synthesis of 4-(dimethylamino)-1,1-dimethoxy-3-buten-2-one from 1,1-dimethoxyacetone and N,N-dimethylformamide dimethyl acetal was as follows: 1,1-dimethoxy-N,N-dimethylformamide (100 g, 839 mmol, 1.02 equiv.) was mixed with 1,1-dimethoxyacetone (97 g, 821 mmol) were mixed and the reaction was stirred at 110 °C for 3 hours. The methanol generated was removed during the reaction via a Dean-Stark device. Upon completion of the reaction, the reaction solution was cooled to room temperature and the remaining volatiles were subsequently removed under vacuum to afford the crude product (E)-4-(dimethylamino)-1,1-dimethoxybut-3-en-2-one (130 g, theoretical yield 143 g, 91% yield). The product was analyzed by LC-MS, m/z 283 (M + 1). Ref: WO 2006/0097341A1 (incorporated by reference), p. 67.
References
[1] Patent: US2012/270892, 2012, A1. Location in patent: Page/Page column 56
[2] Patent: WO2013/2660, 2013, A2. Location in patent: Paragraph 00145; 00146
[3] Tetrahedron, 2008, vol. 64, # 33, p. 7745 - 7758
[4] Patent: WO2004/22553, 2004, A1. Location in patent: Page/Page column 18
[5] Patent: US2011/98272, 2011, A1. Location in patent: Page/Page column 22
1,1-DIMETHOXY-4-DIMETHYLAMINOBUT-3-EN-2-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,1-DIMETHOXY-4-DIMETHYLAMINOBUT-3-EN-2-ONE manufacturers
- Product
- 1,1-DIMETHOXY-4-DIMETHYLAMINOBUT-3-EN-2-ONE 67751-23-9
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2019-07-09