4-Bromo-1-indanone

Product Name: 4-Bromo-1-indanone
CAS No.: 15115-60-3
Chemical Name: 4-Bromo-1-indanone
Synonyms: 4-BROMO-2,3-DIHYDRO-1H-INDEN-1-ONE;SKL642;OZAN-001;4-bromoindanone;4-bromo-1-indanon;4-BROMO-1-INDANONE;4-BROMO-INDAN-1-ONE;1-Indanone, 4-bromo-;4-Bromo-1-indanone,97%;4-Bromo-1-indanone >
CBNumber: CB3310546
Molecular Formula: C9H7BrO
Formula Weight: 211.06
MOL File: 15115-60-3.mol

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4-Bromo-1-indanone Property

Melting point:: 95-99 °C(lit.)
Boiling point:: 125°C/1.5mmHg(lit.)
Density: 1.608±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: Crystalline Powder
color: Orange-brown
InChI: InChI=1S/C9H7BrO/c10-8-3-1-2-7-6(8)4-5-9(7)11/h1-3H,4-5H2
InChIKey: UVVYFYLSZIMKMC-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C(Br)=CC=C2)CC1
CAS DataBase Reference: 15115-60-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 22-60-36
WGK Germany: 2
RTECS: NK7536100
HS Code: 29147000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 644366
Product name: 4-Bromo-1-indanone
Purity: 97%
Packaging: 5g
Price: $353
Updated: 2023/06/20

Sigma-Aldrich

Product number: 644366
Product name: 4-Bromo-1-indanone
Purity: 97%
Packaging: 1g
Price: $83.5
Updated: 2022/05/15

TCI Chemical

Product number: B3801
Product name: 4-Bromo-1-indanone
Purity: >97.0%(GC)
Packaging: 1g
Price: $20
Updated: 2025/07/31

TCI Chemical

Product number: B3801
Product name: 4-Bromo-1-indanone
Purity: >97.0%(GC)
Packaging: 5g
Price: $50
Updated: 2025/07/31

TRC

Product number: B687915
Product name: 4-Bromo-1-indanone
Packaging: 100g
Price: $695
Updated: 2021/12/16

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4-Bromo-1-indanone Chemical Properties,Usage,Production

Chemical Properties

Orange-brown crystalline powder

Uses

4-Bromo-1-indanone is used to prepare N''-indanyl-N-benzopyrazolyl ureas as TRPV1 antagonists for use as analgesics. It is also used to synthesize 1,4-dihydroindeno[1,2-c]pyrazoles as KDR kinase inhibitors.

General Description

4-Bromo-1-indanone is an organic synthetic or pharmaceutical intermediate compound that can be used to prepare the prescription drug Ozanimod. Ozanimod can be used to treat relapsing multiple sclerosis (MS), including clinical solitary syndrome, relapsing-remitting disease and active secondary progressive disease. This drug cannot cure multiple sclerosis, but it can slow down some disabling effects and reduce the frequency of disease recurrence. It can also be used to treat moderate to severe ulcerative colitis.

Synthesis

15115-58-9

15115-60-3

General procedure for the synthesis of 4-bromoinden-1-one from 3-(2-bromophenyl)propionic acid: trifluoromethanesulfonic acid (3 equiv.) was slowly added dropwise at 0 °C to an anhydrous dichloromethane (1.0 mL) solution of 3-(2-bromophenyl)propionic acid (0.5 mmol) which was placed in a 12 mL Q-tube?pressure tube (provided by QLabtech). Subsequently, the reaction mixture was warmed to room temperature. A PTFE septum was placed on top of the reaction tube and sealed using the appropriate cap and pressure adapter. The sealed reaction tube was heated in an oil bath at 80°C. The progress of the reaction was monitored by thin layer chromatography (TLC) and gas chromatography-mass spectrometry (GC/MS) until the reactants completely disappeared. After completion of the reaction, the mixture was poured into ice water and extracted three times with dichloromethane. The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Finally, the target compound 4-bromoinden-1-one was isolated and purified from the crude product by fast column chromatography.

References

[1] Molecules, 2014, vol. 19, # 5, p. 5599 - 5610
[2] Patent: WO2018/106636, 2018, A1. Location in patent: Paragraph 100231
[3] Patent: US2015/25205, 2015, A1. Location in patent: Page/Page column
[4] Patent: WO2015/95188, 2015, A1. Location in patent: Paragraph 00161
[5] Patent: WO2003/99795, 2003, A1. Location in patent: Page 111

4-Bromo-1-indanone Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-1-indanone Suppliers

Americas 1 Austria 1 China 303 Europe 3 France 1 Germany 6 India 13 Japan 1 Slovakia 1 Switzerland 2 Ukraine 1 United Kingdom 18 United States 30 Global 381

Changzhou Qinuo Chemical Co., Ltd.Co., Ltd.

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J & K SCIENTIFIC LTD.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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View Lastest Price from 4-Bromo-1-indanone manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 4-Bromo-1-indanone 15115-60-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-11-27

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Bromo-1-indanone 15115-60-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-15

Henan Aochuang Chemical Co.,Ltd.

Product: 4-Bromo-1-indanone 15115-60-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-19

15115-60-3, 4-Bromo-1-indanoneRelated Search:

1-Indanone 4-Bromo-1H-imidazole 5-Bromo-1-indanone Bromine 5-Bromo-2-indanone 2,2-DIBROMO-1-INDANONE 6-BROMO-1-INDANONE 4-Bromo-2-indanone 2-BROMO-1-INDANONE,2-Bromo-1-indanone, tech., 88-92%,2-BROMO-1-INDANONE: TECH., 85%,2-Bromo-1-indanone , 88-92%,tech. Indan 4-BROMO-6-FLUOROINDAN-1-ONE 4-Bromo-6,7-dimethoxyindanone 4-BROMO-5-ACETAMIDOINDANONE 4-bromo-3-methyl-2,3-dihydro-1H-inden-1-one 1H-Inden-1-one,4-bromo-2,3-dihydro-7-hydroxy- 7-BROMO-1-INDANONE 3-Bromo-1-indanone 4-Bromo-1-indanone

4-bromo-2,3-dihydroinden-1-one

4-Bromo-1-indanone,97%

4-bromoindanone

1H-Inden-1-one, 4-bromo-2,3-dihydro-

1-Indanone, 4-bromo-

4-Bromo-1-indanone≥ 98%(GC)

4-bromo-1-indanon

4-BroMo-1-indanone, >95%

4-BROMO-2,3-DIHYDRO-1H-INDEN-1-ONE

4-BROMO-INDAN-1-ONE

4-BROMO-1-INDANONE

4-BROMO-1-INDANONE HPLC 97%

OZAN-001

4-Bromo-1-indanone &gt

SKL642

15115-60-3

13089-48-2

Carbonyl Compounds

C9

Organic Building Blocks

Ketones

Building Blocks

C9

Carbonyl Compounds

Ketones

Pharmaceutical intermediate

Halides

API intermediates

Benzocycles