3PO
- Product Name
- 3PO
- CAS No.
- 18550-98-6
- Chemical Name
- 3PO
- Synonyms
- 3 PO;3-PO;3PO >=98% (HPLC);inhibitor of glucose metabolism;3PO (inhibitor of glucose metabolism);(E)-3-Pyridin-3-yl-1-pyridin-4-yl-propenone;2-Propen-1-one, 3-(3-pyridinyl)-1-(4-pyridinyl)-, (2E)-
- CBNumber
- CB33121068
- Molecular Formula
- C13H10N2O
- Formula Weight
- 210.23
- MOL File
- 18550-98-6.mol
3PO Property
- Boiling point:
- 387.8±42.0 °C(Predicted)
- Density
- 1.192±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 5 mg/ml)
- form
- powder
- pka
- 3.49±0.11(Predicted)
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1343
- Product name
- 3PO
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $74.6
- Updated
- 2023/06/20
- Product number
- SML1343
- Product name
- 3PO
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $287
- Updated
- 2023/06/20
- Product number
- 19276
- Product name
- 3PO
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 19276
- Product name
- 3PO
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $54
- Updated
- 2024/03/01
- Product number
- 19276
- Product name
- 3PO
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $116
- Updated
- 2024/03/01
3PO Chemical Properties,Usage,Production
Description
3PO (18550-98-6) is an inhibitor of the metabolic enzyme 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3).? PFKFB3 is constitutively expressed by neoplastic cells and is required for the high glycolytic rate (Warburg Effect) of these cells. 3PO inhibits PFKFB3 (IC50?= 1.4 – 24 μM for various cancer cell lines), suppresses glucose uptake, and lowers intracellular concentrations of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.1? Inhibition of cancer cell metabolism via blocking the action of PFKFB3 has been studied in various models.2-4? Inhibition of PFKFB3 has been shown to induce autophagy as a survival mechanism in cancer cells.5? 3PO has also been used to reduce pathological angiogenesis.6
Definition
ChEBI: 3PO is a member of the class of pyridines that is pyridine substituted by a 3-oxo-3-(pyridin-4-yl)prop-1-en-1-yl group at position 3. An inhibitor of PFKFB3 kinase, an enzyme with a key role in glycolysis. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an autophagy inducer, an apoptosis inducer and an EC 2.7.1.105 (6-phosphofructo-2-kinase) inhibitor. It is a member of pyridines and an enone.
Biochem/physiol Actions
3PO is a potent and selective inhibitor of PFKFB3 (6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase) that reduces glycolytic flux and suppresses glucose uptake. 3PO is selectively cytostatic to transformed cells and suppresses the growth of established tumor in mice.
References
1) Clem?et al.?(2008),?Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth; Mol. Cancer Ther.?7?110 2) Clem?et al.?(2013),?Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer; Mol. Cancer Ther.?12?1461 3) Lea?et al.?(2015),?Inhibition of Growth of Bladder Cancer Cells by 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one in Combination with Other Compounds Affecting Glucose Metabolism; Anticancer Res.?35?5889 4) Lea?et al.?(2016),?Inhibition of Growth by Combined Treatment with Inhibitors of Lactate Dehydrogenase and either Phenformin or Inhibitors of 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatae 3; Anticancer Res.?36?1479 5) Klarer?et al.?(2014),?Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism; Cancer Metab.?2?2 6) Schoors?et al.?(2014),?Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis; Cell Metab.?19?37
3PO Preparation Products And Raw materials
Raw materials
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