G-5555
- Product Name
- G-5555
- CAS No.
- 1648863-90-4
- Chemical Name
- G-5555
- Synonyms
- G-5555;G5555;G 5555;PAK1 inhibitor (g-5555);p21 activated kinases,G-5555,PAK,Inhibitor,G 5555,inhibit,G5555;8-(((2r,5r)-5-Amino-1,3-dioxan-2-yl)methyl)-6-(2-chloro-4-(6-methylpyridin-2-yl)phenyl)-2-(met;8-((trans-5-Amino-1,3-dioxan-2-yl)methyl)-6-(2-chloro-4-(6-methylpyridin-2-yl)phenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one;8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one;Pyrido[2,3-d]pyrimidin-7(8H)-one, 8-[(trans-5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-
- CBNumber
- CB33126700
- Molecular Formula
- C25H25ClN6O3
- Formula Weight
- 492.96
- MOL File
- 1648863-90-4.mol
G-5555 Property
- Boiling point:
- 684.6±65.0 °C(Predicted)
- Density
- 1.363±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS(pH 7.2) (1:4): 0.20 mg/ml
- form
- A crystalline solid
- pka
- 6.86±0.40(Predicted)
- color
- White to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML3237
- Product name
- G-5555
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $102
- Updated
- 2023/06/20
- Product number
- SML3237
- Product name
- G-5555
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $409
- Updated
- 2023/06/20
- Product number
- 21469
- Product name
- G-5555
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 21469
- Product name
- G-5555
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $79
- Updated
- 2024/03/01
- Product number
- 21469
- Product name
- G-5555
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $330
- Updated
- 2024/03/01
G-5555 Chemical Properties,Usage,Production
Description
G-5555 is an inhibitor of p21-activated kinase 1 (PAK1; Ki = 3.7 nM), a non-receptor serine/threonine kinase involved in tumorigenesis. It is selective for PAK1 over the majority of targets in a panel of 235 kinases but does inhibit PAK2, PAK3, KHS1, LCK, MST3, MST4, SIK2, and YSK1 by greater than 70% with IC50 values ranging from 9 to 52 nM. G-5555 inhibits phosphorylation of MEK, a downstream target of PAK1, in EBC1 cells (IC50 = 69 nM). G-5555 (10, 20, and 30 mg/kg) dose-dependently reduces phosphorylation of MEK in tumors from an H292 non-small cell lung cancer (NSCLC) mouse xenograft model. G-5555 inhibits hERG channels less than 50% at a concentration of 10 μM, indicating the potential for a low risk of QT interval prolongation and potentially fatal arrhythmias.
Uses
G 5555 is a high affinity group 1 p21-activated kinases (PAK) inhibitor.
storage
Store at -20°C
G-5555 Preparation Products And Raw materials
Raw materials
Preparation Products
G-5555 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77