2-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER
- Product Name
- 2-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER
- CAS No.
- 108354-78-5
- Chemical Name
- 2-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER
- Synonyms
- AKOS B000467;AKOS BBB/011;ASISCHEM Z95321;AKOS BBS-00000703;CHEMBRDG-BB 3000467;ART-CHEM-BB B000467;methyl 2-amino-4,5,6,7-tetrahydrobenzothiophene-3-carboxylate;METHYL 2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXYLATE;Methyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate;Methyl 2-aMino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate, 98%
- CBNumber
- CB3312696
- Molecular Formula
- C10H13NO2S
- Formula Weight
- 211.28
- MOL File
- 108354-78-5.mol
2-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER Property
- Melting point:
- 128-131°C
- Boiling point:
- 399.0±42.0 °C(Predicted)
- Density
- 1.273±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 0.52±0.20(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 108354-78-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M286615
- Product name
- Methyl2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- M286615
- Product name
- Methyl2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 023866
- Product name
- Methyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
- Packaging
- 500mg
- Price
- $10
- Updated
- 2021/12/16
- Product number
- 023866
- Product name
- Methyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
- Packaging
- 1g
- Price
- $18
- Updated
- 2021/12/16
- Product number
- 2477CH
- Product name
- Methyl2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
- Packaging
- 5g
- Price
- $104
- Updated
- 2021/12/16
2-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production
Synthesis
108-94-1
105-34-0
108354-78-5
Methyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (Compound 1) was synthesized from cyclohexanone and methyl cyanoacetate by standard Gewald reaction. The procedure was as follows: to a stirred solution of cyclohexanone (4.91 g, 0.05 mol), methyl cyanoacetate (4.95 g, 0.05 mol), and sulfur (1.92 g, 0.06 mol) in 35 mL of ethanol, morpholine (4.4 g, 0.05 mol) was slowly added dropwise. After the dropwise addition was completed, the reaction mixture was refluxed for 3 hours. After completion of the reaction, it was cooled to room temperature and the precipitate was collected by filtration. Purification by ethanol recrystallization gave a light yellow powdery product (8.6 g, 82% yield). The melting point of the product was 128.2-129.4 °C (literature value: 128-130 °C), and mass spectrometry (GC-MS) analysis showed a m/z of 211 [M + H]+ and fragment ion peaks of 179, 151, 125, 91, 77, 65, 53.
References
[1] Asian Journal of Chemistry, 2010, vol. 22, # 9, p. 7399 - 7404
[2] Organic and Biomolecular Chemistry, 2014, vol. 12, # 12, p. 1942 - 1956
[3] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 8, p. 1866 - 1871
[4] Tetrahedron, 2006, vol. 62, # 29, p. 7121 - 7131
[5] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 8, p. 1947 - 1953
2-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials
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View Lastest Price from 2-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER manufacturers
- Product
- 2-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER 108354-78-5
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-10