BDA-366

Product Name: BDA-366
CAS No.: 1909226-00-1
Chemical Name: BDA-366
Synonyms: 1-[[(2S)-3-(Diethylamino)-2-hydroxypropyl]amino]-4-[[(2S)-2-oxiranylmethyl]amino]-9,10-anthracenedione;9,10-Anthracenedione, 1-[[(2S)-3-(diethylamino)-2-hydroxypropyl]amino]-4-[[(2S)-2-oxiranylmethyl]amino]-;Inhibitor,BDA-366,Antitumor,Bcl-2 Family,inhibit,Bcl2-BH4 domain,Anticancer,BDA 366,Antiapoptotic function,Lung cancer,BDA366
CBNumber: CB33128810
Molecular Formula: C24H29N3O4
Formula Weight: 423.5
MOL File: 1909226-00-1.mol

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BDA-366 Property

Boiling point:: 669.4±55.0 °C(Predicted)
Density: 1.313±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: A solid
pka: 14.21±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B5978
Product name: BDA-366
Packaging: 5mg
Price: $296
Updated: 2021/12/16

ApexBio Technology

Product number: B5978
Product name: BDA-366
Packaging: 25mg
Price: $1047
Updated: 2021/12/16

DC Chemicals

Product number: DC9709
Product name: BDA-366
Purity: >98%
Packaging: 1g
Price: $2200
Updated: 2021/12/16

CSNpharm

Product number: CSN18845
Product name: BDA-366
Packaging: 10mg
Price: $257
Updated: 2021/12/16

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BDA-366 Chemical Properties,Usage,Production

Definition

ChEBI: BDA-366 is a member of the class of anthraquinone that is 1,4-diamino-9,10-anthraquinone in which the two amino groups are carrying 3-(diethylamino)-2-hydroxypropyl and (oxiran-2-yl)methyl substituents. It exhibits anti-cancer properties. It has a role as an antineoplastic agent and an apoptosis inducer. It is an anthraquinone, an epoxide, a tertiary amino compound, a secondary amino compound and a secondary alcohol. It is functionally related to a 9,10-anthraquinone.

Biological Activity

bda-366 is a selective antagonist of bcl2 bh4 domain with ki value of 3.3 nm [1].bcl2 is an important anti-apoptotic protein. bcl2 homology 4 (bh4) domain is required for its antiapoptotic function, thus acts as a promising anticancer target [1].bda-366 is a selective bcl2 inhibitor. bda-366 induced conformational change of bcl2 that exposed the bh3 domain, resulting in abrogation of its prosurvival function and conversion of bcl2 to a prodeath protein. in non-small cell lung cancer (nsclc) and small cell lung cancer (sclc) cells, bda-366 selectively bound to bcl2 with high affinity. bda-366 induced apoptosis by bcl2-dependent bax activation and cytochrome c release. in h460 cells, bda-366 reduced bcl2/ip3r binding, which then increased ca2+ release [1].in mice bearing h460 lung cancer xenografts, treatment with bda-366 (0, 10, 20, and 30 mg/kg/day) via i.p. route for 14 days induced apoptosis and potently inhibited tumor growth in a dose-dependent way. there was no significant toxicity at the maximum therapeutic dose. in tumor tissue from patients with nsclc, bda-366 synergized with rad001 and resulted in significantly greater inhibition of lung cancer growth compared with either agent alone [1].

References

[1]. han b, park d, li r, et al. small-molecule bcl2 bh4 antagonist for lung cancer therapy. cancer cell, 2015, 27(6): 852-863.

BDA-366 Preparation Products And Raw materials

Raw materials

Preparation Products

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BDA-366 Suppliers

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1909226-00-1, BDA-366Related Search:

1-[[(2S)-3-(Diethylamino)-2-hydroxypropyl]amino]-4-[[(2S)-2-oxiranylmethyl]amino]-9,10-anthracenedione

Inhibitor,BDA-366,Antitumor,Bcl-2 Family,inhibit,Bcl2-BH4 domain,Anticancer,BDA 366,Antiapoptotic function,Lung cancer,BDA366

9,10-Anthracenedione, 1-[[(2S)-3-(diethylamino)-2-hydroxypropyl]amino]-4-[[(2S)-2-oxiranylmethyl]amino]-

1909226-00-1