Flomoxef Impurity 5
- Product Name
- Flomoxef Impurity 5
- CAS No.
- 134237-56-2
- Chemical Name
- Flomoxef Impurity 5
- Synonyms
- Flomoxef Nucleus;Flomoxef sodium Impurity 5;(6R,7R)-benzhydryl (7-(2-difluoromethylthio)acetamido)-3-(chloromethyl)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4,2,0]oct-2-ene-2-carboxylate;5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-(chloromethyl)-7-[[[(difluoromethyl)thio]acetyl]amino]-7-methoxy-8-oxo-, diphenylmethyl ester, (6R-cis)- (9CI)
- CBNumber
- CB33129600
- Molecular Formula
- C25H23ClF2N2O6S
- Formula Weight
- 552.97
- MOL File
- 134237-56-2.mol
Flomoxef Impurity 5 Property
- Boiling point:
- 727.8±60.0 °C(Predicted)
- Density
- 1.46±0.1 g/cm3(Predicted)
- pka
- 11.28±0.60(Predicted)
Flomoxef Impurity 5 Chemical Properties,Usage,Production
Uses
(6R,7R)-benzhydryl (7-(2-difluoromethylthio)acetamido)-3-(chloromethyl)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4,2,0]oct- 2-ene-2-carboxylate is an impurity intermediate mainly used in laboratory R&D and pharmaceutical R&D.
Synthesis
451 mL ofdichloromethane, 2- (difluoro-methylthio) acetic acid 49.6 g, 144.8 mL pyridine was added to reactorand cooled to -40 ° C. (6R, 7R)-benzhydryl-7-amino-3-(chloromethyl)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylatein dichloromethane 1080 mL was added to the reactor and temperature wasmaintained at -25 ° C. After the reactionsolution was cooled below -45 ° C, 42 mL of phosphorous oxychloride in 180.4 mLdichloromethane was added at -15°C and stirred for 30 minutes. After checking completion of the reaction1262.8 ml of purified water, 4.59 ml of 35% hydrochloric acid, 2.7 ml of 50%tetrabutylammonium bromide was added dropwise at 0°C, which in turn stirred for10 minutes. Then, 1262.8 ml of methanol was added at 0°C and stirred for 10 minutes. then separating the layer. 902 mL ethanol added to the filtrate and then stirred for 2 hours at -10 and washed with 360.8 mL of ethanol, and a white or slightly yellow horse crystal component of the vacuum-dried for 10 hours at 40 was added (6R,7R)-benzhydryl (7-(2-difluoromethylthio)acetamido)-3-(chloromethyl)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4,2,0]oct-2-ene-2-carboxylate (146.7g, 76%).
Flomoxef Impurity 5 Preparation Products And Raw materials
Raw materials
Preparation Products
Flomoxef Impurity 5 Suppliers
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 17982
- Advantage
- 56
- Tel
- 020-81716320 17788709170
- Fax
- 020-81716319
- Sales@pipitech.com
- Country
- China
- ProdList
- 2649
- Advantage
- 58
- Tel
- +86-400-002-6226 13028896684
- sales@rrkchem.com
- Country
- China
- ProdList
- 55827
- Advantage
- 58
- Tel
- 2710913286@.com
- 1513643261@qq.com
- Country
- China
- ProdList
- 14253
- Advantage
- 58
- Tel
- 020-81215950 4000-868-328
- customer@uwalab.com
- Country
- United States
- ProdList
- 10413
- Advantage
- 58
- Tel
- 12345678910
- Fax
- nanfengdrug@163
- nanfengdrug@163.com
- Country
- China
- ProdList
- 15323
- Advantage
- 58
- Tel
- 18672616696
- 229092275@qq.com
- Country
- China
- ProdList
- 707
- Advantage
- 58
- Tel
- 13670046396
- ORDERS@QCSRM.COM
- Country
- China
- ProdList
- 18810
- Advantage
- 58
- Tel
- 17691182729 18161915376
- 1046@dideu.com
- Country
- China
- ProdList
- 10008
- Advantage
- 58
- Tel
- 17727342298
- 2781109436@qq.com
- Country
- China
- ProdList
- 2004
- Advantage
- 58