MP-A08
- Product Name
- MP-A08
- CAS No.
- 219832-49-2
- Chemical Name
- MP-A08
- Synonyms
- MP-A08;MPA08,SphK,Sphingosine kinase,MP-A-08,inhibit,Inhibitor,MP-A08,MP A08;4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide;4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide;4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide , MP-A08;Benzenesulfonamide, 4-methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]-
- CBNumber
- CB33133348
- Molecular Formula
- C27H25N3O4S2
- Formula Weight
- 519.64
- MOL File
- 219832-49-2.mol
MP-A08 Property
- Boiling point:
- 717.1±70.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- solubility
- DMF: 33 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 12 mg/ml
- form
- A crystalline solid
- pka
- 7.88±0.10(Predicted)
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 21903
- Product name
- MP-A08
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 21903
- Product name
- MP-A08
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $96
- Updated
- 2024/03/01
- Product number
- 21903
- Product name
- MP-A08
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $176
- Updated
- 2024/03/01
- Product number
- 21903
- Product name
- MP-A08
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $396
- Updated
- 2024/03/01
- Product number
- 5803
- Product name
- MPA08
- Packaging
- 10
- Price
- $168
- Updated
- 2021/12/16
MP-A08 Chemical Properties,Usage,Production
Description
MP-A08 is an ATP-competitive inhibitor of sphingosine kinases SPHK1 and SPHK2 (Kis = 27 and 6.9 μM, respectively). It is selective for SPHK1/2 over a panel of 140 human protein kinases at concentrations up to 25 μM. MP-A08 (15 μM) reduces generation of cellular sphingosine-1-phosphate (S1P; ) without inducing degradation of SPHK1 in Jurkat cells. It induces a 3.7-, 3.5-, and 5.8-fold increase in C-18 ceramide , C-20 ceramide , and C20:1-ceramide levels, respectively, and dose-dependently activates the apoptosis-associated p38 and JNK pathways in vitro. MP-A08 reduces proliferation of a variety of human cancer cell lines (EC50s = 8-44.9 μM). MP-A08 also reduces tumor vasculature, as determined by CD31 staining, and volume as well as S1P protein levels in A549 human lung adenocarcinoma xenografts in mice.
Uses
NSC 122314 is selective ATP competitive sphingosine kinase 2 and 1 inhibitor. Also it induces mitochondrial-associated apoptosis.
Definition
ChEBI: MP-A08 is a sulfonamide that consists of two moieties of 4-methyl-N-phenylbenzenesulfonamide connected to each other at position 2 by an aldimine linker. It is a ATP-competitive inhibitor of sphingosine kinase that targets both SK1 and SK2 (Ki values of 27 muM and 6.9 muM, respectively) and exhibits anti-cancer properties. It has a role as an antineoplastic agent, an apoptosis inducer, an angiogenesis inhibitor and an EC 2.7.1.91 (sphingosine kinase) inhibitor. It is a sulfonamide, a member of toluenes and an aldimine.
storage
Store at -20°C
MP-A08 Preparation Products And Raw materials
Raw materials
Preparation Products
MP-A08 Suppliers
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