7BIO

ChemicalBook > CAS DataBase List > 7BIO

Product Name: 7BIO
CAS No.: 916440-85-2
Chemical Name: 7BIO
Synonyms: 7BIO;7BIO, 10 mM in DMSO;7BIO - CAS 916440-85-2 - Calbiochem;7'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one;7'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one;2H-Indol-2-one, 7-bromo-3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-;tau hyper-phosphorylation,7BIO,cognitive impairment,GSK3β,Cyclin dependent kinase,GSK-3,synaptic impairments,CDK,Inhibitor,CDK5,inhibit,activation of astrocytes and microglia,Glycogen synthase kinase 3,Aβ oligomer,neuroinflammation,Glycogen synthase kinase-3
CBNumber: CB33136738
Molecular Formula: C16H10BrN3O2
Formula Weight: 356.17
MOL File: 916440-85-2.mol

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7BIO Property

storage temp.: +2C to +8C
solubility: Soluble in ethanol;DMSO
form: Deep black-red solid
color: Dark red

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19619
Product name: 7BIO
Purity: ≥99%
Packaging: 10mg
Price: $157
Updated: 2024/03/01

Cayman Chemical

Product number: 19619
Product name: 7BIO
Purity: ≥99%
Packaging: 50mg
Price: $623
Updated: 2024/03/01

TRC

Product number: B591703
Product name: 7BIO
Packaging: 25mg
Price: $420
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0008614
Product name: 7BIO
Purity: 95.00%
Packaging: 5MG
Price: $500.03
Updated: 2021/12/16

Adipogen Life Sciences

Product number: AG-MR-C0020-M050
Product name: 7BIO
Purity: ≥99%(NMR)
Packaging: 50mg
Price: $520
Updated: 2021/12/16

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7BIO Chemical Properties,Usage,Production

Description

7BIO is a derivative of indirubin that triggers a rapid cell death process that is distinct from apoptosis and devoid of cytochrome c release or caspase activation. Furthermore, in contrast to other indirubin derivatives, 7BIO has only marginal activity against the classic indirubin targets, cyclin-dependent kinases and GSK3. Instead, 7BIO inhibits FLT3 (IC₅₀ = 0.34 μM) and the dual-specificity tyrosine phosphorylation-regulated kinases, DYRK1A and DYRK2 (IC₅₀s = 1.9 and 1.3 μM, respectively). It also inhibits Aurora B and C kinases with IC₅₀ values of 4.6 and 0.7 μM, respectively.

Uses

7BIO is a caspase independent nonapoptotic cell death inducer.

storage

+4°C

References

[1] ribas j, bettayeb k, ferandin y, et al. 7-bromoindirubin-3′-oxime induces caspase-independent cell death[j]. oncogene, 2006, 25(47): 6304-6318.
[2] myrianthopoulos v, kritsanida m, gaboriaud-kolar n, et al. novel inverse binding mode of indirubin derivatives yields improved selectivity for dyrk kinases[j]. acs medicinal chemistry letters, 2012, 4(1): 22-26.
[3] myrianthopoulos v, magiatis p, ferandin y, et al. an integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases b and c by a series of 7-substituted indirubins[j]. journal of medicinal chemistry, 2007, 50(17): 4027-4037.

7BIO Preparation Products And Raw materials

Raw materials

Preparation Products

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7BIO Suppliers

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916440-85-2, 7BIORelated Search:

7BIO

7BIO - CAS 916440-85-2 - Calbiochem

2H-Indol-2-one, 7-bromo-3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-

tau hyper-phosphorylation,7BIO,cognitive impairment,GSK3β,Cyclin dependent kinase,GSK-3,synaptic impairments,CDK,Inhibitor,CDK5,inhibit,activation of astrocytes and microglia,Glycogen synthase kinase 3,Aβ oligomer,neuroinflammation,Glycogen synthase kinase-3

7'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one

7BIO, 10 mM in DMSO

916440-85-2