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CPI-1205

Product Name
CPI-1205
CAS No.
1621862-70-1
Chemical Name
CPI-1205
Synonyms
1205;CPDB1215;CPI-1205;CPI‑CPI-1205 (CPI 1205;Lirametostat ( CPI-1205 );Coconut amine polyoxyethylene ether CA1202;N-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-1-[(1R)-1-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]ethyl]indole-3-carboxamide;(R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide;1H-Indole-3-carboxamide, N-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-2-methyl-1-[(1R)-1-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]ethyl]-
CBNumber
CB33145567
Molecular Formula
C27H33F3N4O3
Formula Weight
518.57
MOL File
1621862-70-1.mol
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CPI-1205 Property

Boiling point:
692.5±55.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
11.01±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology
Product number
B7819
Product name
CPI-1205
Packaging
50mg
Price
$1733
Updated
2021/12/16
Chemenu
Product number
CM328325
Product name
N-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-1-[(1R)-1-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]ethyl]indole-3-carboxamide
Purity
95%+
Packaging
1g
Price
$9280
Updated
2021/12/16
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CPI-1205 Chemical Properties,Usage,Production

Biological Activity

0.002 μm for biochemical ic50; 0.032 μm for cellular ec50.cpi-1205 is an ezh2 inhibitor.polycomb repressive complex 2 (prc2) plays a key role in transcriptional silencing partially by installing methylation marks on lysine 27 of histone 3. dysregulation of prc2 function relates with certain malignancies and poor prognosis. ezh2 is thus representing a promising candidate oncology target for pharmacological intervention.

in vitro

previous study reported that the treatment with cpi-1205 caused apoptosis in multiple myeloma and plasmacytoma cell models. cpi-1205 also had a clean selectivity profile when tested against 30 other histone or dna methyltransferases. in addition, cpi-1205 demonstrated modest selectivity when tested against enhancer of zeste homologue 1 (ezh1) that is a methyltransferase highly related to ezh2 [1].

in vivo

in animal study, cpi-1205 was dosed at 160 mg/kg orally twice daily for 25 days in tumor bearing female cb-17 scid mice. by the treatment of tumor-bearing mice with cpi-1205, tumor regression was observed within two weeks. by the end of day 25, significant tumor growth inhibition was recorded. cpi-1205 was found to be well-tolerated for repeat dosing as observed by the absence of significant body weight loss. in addition, analysis of plasma and tumor at 1 h post last dose on day 25 showed sufficient plasma and tumor tissue concentrations [1].

References

[1] vaswani rg et al. identification of (r)-n-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1h-indole-3-carboxamide (cpi-1205), a potent and selective inhibitor of histone methyltransferase ezh2, suitable for phase i

CPI-1205 Preparation Products And Raw materials

Raw materials

Preparation Products

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CPI-1205 Suppliers

MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

1621862-70-1, CPI-1205Related Search:


  • CPI-1205
  • CPI-1205 (CPI 1205
  • CPDB1215
  • (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide
  • N-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-1-[(1R)-1-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]ethyl]indole-3-carboxamide
  • 1H-Indole-3-carboxamide, N-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-2-methyl-1-[(1R)-1-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]ethyl]-
  • Lirametostat ( CPI-1205 )
  • 1205
  • CPI&#8209
  • Coconut amine polyoxyethylene ether CA1202
  • 1621862-70-1
  • C27H33F3N4O3