ChemicalBook > CAS DataBase List > KRIBB11

KRIBB11

Product Name: KRIBB11
CAS No.: 342639-96-7
Chemical Name: KRIBB11
Synonyms: CS-2403;KRIBB11;KRIBB 11;KRIBB-11;KRIBB11, 10 mM in DMSO;N2-1H-Indazol-5-yl-N6-methyl-3-nitro-2,6-pyridinediamine;N2-(1H-Indazol-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine;2,6-Pyridinediamine, N2-1H-indazol-5-yl-N6-methyl-3-nitro-;KRIBB11,KRIBB 11,HSP,Apoptosis,Inhibitor,inhibit,Heat shock proteins,KRIBB-11
CBNumber: CB33146317
Molecular Formula: C13H12N6O2
Formula Weight: 284.27
MOL File: 342639-96-7.mol

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KRIBB11 Property

Boiling point:: 534.9±50.0 °C(Predicted)
Density: 1.531±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO:27.0(Max Conc. mg/mL);94.98(Max Conc. mM)
form: powder
pka: 13.59±0.40(Predicted)
color: yellow to orange

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1412
Product name: KRIBB11 trifluoroacetate salt
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $87.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1412
Product name: KRIBB11 trifluoroacetate salt
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $268
Updated: 2025/07/31

Sigma-Aldrich

Product number: 385570
Product name: Heat Shock Factor 1 Inhibitor, KRIBB11
Purity: The Heat Shock Factor 1 Inhibitor, KRIBB11 controls the biological activity of Heat Shock Factor 1.
Packaging: 10 mg
Price: $126
Updated: 2025/07/31

Cayman Chemical

Product number: 9002528
Product name: KRIBB11
Purity: ≥95%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 9002528
Product name: KRIBB11
Purity: ≥95%
Packaging: 10mg
Price: $115
Updated: 2024/03/01

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KRIBB11 Chemical Properties,Usage,Production

Uses

KRIBB 11 is a heat shock factor (HSF) inhibitor that induces apoptosis in cancer cells. KRIBB 11 exhibits anticancer properties.

Biological Activity

KRIBB11 is an inhibitor of the transcription factor He at Shock Factor 1 (HSF1) with an IC50 value of 1.2 μM. KRIBB11 blocks induction of HSF1 downstream target proteins such as HSP27 and HSP70 by impairing the recruitment of Positive Transcription Elongation Factor b (P-TEFb) to the HSF1 transcriptional complex, preventing HSF1-mediated gene expression KRIBB11 inhibits tumor growth in vivo and acts synergistically to increase apoptosis in cancer cells treated with the HSP90 inhibitors Geldanamycin and 17-AAG.', 'KRIBB11 is capable of preventing the proliferation of cancer cells. It has the ability to stimulate apoptosis and can arrest the cell cycle at G2/M phase.

Synthesis

342639-94-5

74-89-5

342639-96-7

Example 3 Preparation of N2-(1H-indazol-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine To a reaction flask containing methanol with 40% aqueous methylamine (20 mL) was added 2-(1H-indazol-5-ylamino)-6-methoxy-3-nitropyridine (1 g) obtained by Example 1. The reaction mixture was stirred at 25°C for 1 hour. Subsequently, deionized water (20 mL) was slowly added to the reaction mixture and stirring was continued for 1 hour. After completion of the reaction, the reaction mixture was filtered and the solid product was washed with 30% aqueous methanol (5 mL). The resulting solid product was dried under vacuum at 50-60 °C to afford the target compound N2-(1H-indazol-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine (0.82 g, 82% yield). Melting point: 238-240 °C. 1H-NMR (DMSO-d6, δ, ppm): 2.86 (d, 3H), 6.09 (d, 1H), 7.51 (d, 1H), 7.57 (d, 1H), 8.05 (t, 2H), 8.24 (d, 2H), 10.97 (s, 1H), 13.05 (br s, 1H).

storage

Store at -20°C

References

[1] Patent: US6743795, 2004, B1. Location in patent: Page/Page column 8

KRIBB11 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from KRIBB11 manufacturers

Career Henan Chemical Co

Product: KRIBB11 342639-96-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

342639-96-7, KRIBB11Related Search:

KRIBB11

CS-2403

KRIBB 11;KRIBB-11

N2-1H-Indazol-5-yl-N6-methyl-3-nitro-2,6-pyridinediamine

2,6-Pyridinediamine, N2-1H-indazol-5-yl-N6-methyl-3-nitro-

N2-(1H-Indazol-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine

KRIBB11,KRIBB 11,HSP,Apoptosis,Inhibitor,inhibit,Heat shock proteins,KRIBB-11

KRIBB11, 10 mM in DMSO

342639-96-7