Tat-NR2B9c

Product Name: Tat-NR2B9c
CAS No.: 500992-11-0
Chemical Name: Tat-NR2B9c
Synonyms: Tat-NR2B9c;Tat-NR2B9c/NA-1;Tat-NR2B9c, >98%;Tat-NR2Bct|||NA-1;tat-nr2b9c ，P1220;500992-11-0/1834571-04-8;Tat-NR2B9c trifluoroacetate;L-Valine, L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-lysyl-L-leucyl-L-seryl-L-seryl-L-isoleucyl-L-α-glutamyl-L-seryl-L-α-aspartyl-;(2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,41S,44S,47S,50S,53S,59S)-59-Amino-38-(3-amino-3-oxopropyl)-26,47,50-tris(4-aminobutyl)-14-((S)-sec-butyl)-11-(2-carboxyethyl)-5-(carboxymethyl)-29,32,35,41,44,53-hexakis(3-guanidinopropyl)-8,17,20-tris(hydroxymethyl)-60-(4-hydroxyphenyl)-23-isobutyl-2-isopropyl-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,55,58-nonadecaoxo-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-nonadecaazahexacontanoic acid
CBNumber: CB33146625
Molecular Formula: C105H188N42O30
Formula Weight: 2518.88
MOL File: 500992-11-0.mol

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Tat-NR2B9c Property

Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
form: Solid
color: White to off-white
Water Solubility: Water : ≥ 50 mg/mL (19.85 mM)

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5808
Product name: Tat-NR2B9c
Packaging: 1mg
Price: $84
Updated: 2021/12/16

ChemScene

Product number: CS-5808
Product name: Tat-NR2B9c
Packaging: 5mg
Price: $216
Updated: 2021/12/16

ChemScene

Product number: CS-5808
Product name: Tat-NR2B9c
Packaging: 10mg
Price: $336
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611422
Product name: Tat-NR2B9c
Packaging: 5mg
Price: $382.5
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611422
Product name: Tat-NR2B9c
Packaging: 10mg
Price: $460.7
Updated: 2021/12/16

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Tat-NR2B9c Chemical Properties,Usage,Production

Uses

Tat-NR2B9c (Tat-NR2Bct; NA-1) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c also inhibits?neuronal nitric oxide synthase (nNOS)/PSD-95?interaction, and possesses neuroprotective efficacy[1][2][5].

Biological Activity

Tat-NR2B9c (NA-1) is a 20-mer peptide composed of a membrane-permeant HIV-1 T at protein transduction domain sequence (a.a. 47-57) N-terminal to the NMDA receptor (NMDAR) GluN2B carboxyl tail sequence KLSSIESDV th at blocks intracellular NMDAR-PSD-95 interaction-induced neurotoxic signaling without affecting NMDAR-mediated synaptic activity or calcium influx. NA-1 protects cultured cortical neurons from NMDA excitotoxicity (50 nM; 20/40/100 μM NMDA) and reduces focal ischemic brain damage in rats in vivo (3 μmol/kg iv. bolus 1 hr post MCAO onset).

in vivo

Tat-NR2B9c (10?nmol/g, i.v.) reduces infarction volume of male C57BL/6 mice, but has no effect at 3?nM/g^[3].

IC 50

NMDA Receptor; nNOS

References

[1] Cui H, et al. PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J Neurosci. 2007 Sep 12;27(37):9901-15. DOI:10.1523/JNEUROSCI.1464-07.2007
[2] Fan J, et al. P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease. Neurobiol Dis. 2012 Mar;45(3):999-1009. DOI:10.1016/j.nbd.2011.12.019
[3] Teves LM, et al. Efficacy of the PSD95 inhibitor Tat-NR2B9c in mice requires dose translation between species. J Cereb Blood Flow Metab. 2016 Mar;36(3):555-61. DOI:10.1177/0271678X15612099
[4] Jing Fan, et al. N-methyl-D-aspartate Receptor Subunit- And Neuronal-Type Dependence of Excitotoxic Signaling Through Post-Synaptic Density 9. J Neurochem. 2010 Nov;115(4):1045-56. DOI:10.1111/j.1471-4159.2010.06994.x

Tat-NR2B9c Preparation Products And Raw materials

Raw materials

Preparation Products

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Tat-NR2B9c Suppliers

China 52 United States 5 Global 57

MedChemexpress LLC

Tel: 021-58955995
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Wuxi Zhongkun Biochemical Technology Co., Ltd.

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Email: sales@reading-chemicals.com
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Creative Peptides

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Shanghai Chaolan Chemical Technology Center

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Email: Sales@ATKchemical.com
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Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
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Chengdu Youngshe Chemical Co., Ltd.

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Musechem

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Hangzhou Peptidego Biotech Co.,Ltd.

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Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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500992-11-0, Tat-NR2B9cRelated Search:

Tat-NR2B9c

Tat-NR2B9c, >98%

L-Valine, L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-lysyl-L-leucyl-L-seryl-L-seryl-L-isoleucyl-L-α-glutamyl-L-seryl-L-α-aspartyl-

Tat-NR2B9c/NA-1

500992-11-0/1834571-04-8

(2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,41S,44S,47S,50S,53S,59S)-59-Amino-38-(3-amino-3-oxopropyl)-26,47,50-tris(4-aminobutyl)-14-((S)-sec-butyl)-11-(2-carboxyethyl)-5-(carboxymethyl)-29,32,35,41,44,53-hexakis(3-guanidinopropyl)-8,17,20-tris(hydroxymethyl)-60-(4-hydroxyphenyl)-23-isobutyl-2-isopropyl-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,55,58-nonadecaoxo-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-nonadecaazahexacontanoic acid

Tat-NR2Bct|||NA-1

Tat-NR2B9c trifluoroacetate

tat-nr2b9c ，P1220

500992-11-0

C105H188N42O30