(R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol

Product Name: (R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol
CAS No.: 1203490-23-6
Chemical Name: (R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol
Synonyms: EPI002;Ralaniten, 10 mM in DMSO;(R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol;(R)-3-[4-[1-[4-[(S)-3-Chloro-2-hydroxypropoxy] phenyl]-1-methylethyl]phenoxy]-1,2-propanediol;1,2-Propanediol, 3-[4-[1-[4-[(2S)-3-chloro-2-hydroxypropoxy]phenyl]-1-methylethyl]phenoxy]-, (2R)-
CBNumber: CB33150833
Molecular Formula: C21H27ClO5
Formula Weight: 394.89
MOL File: 1203490-23-6.mol

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(R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol Property

Boiling point:: 601.0±55.0 °C(Predicted)
Density: 1.228±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO : 100 mg/mL (253.24 mM; Need ultrasonic)
form: Solid
pka: 13.13±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ambeed

Product number: A1167310
Product name: (R)-3-(4-(2-(4-((S)-3-Chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol
Purity: 97%
Packaging: 25mg
Price: $454
Updated: 2021/12/16

Ambeed

Product number: A1167310
Product name: (R)-3-(4-(2-(4-((S)-3-Chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol
Purity: 97%
Packaging: 50mg
Price: $696
Updated: 2021/12/16

Ambeed

Product number: A1167310
Product name: (R)-3-(4-(2-(4-((S)-3-Chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol
Purity: 97%
Packaging: 100mg
Price: $950
Updated: 2021/12/16

Ambeed

Product number: A1167310
Product name: (R)-3-(4-(2-(4-((S)-3-Chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol
Purity: 97%
Packaging: 250mg
Price: $1483
Updated: 2021/12/16

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(R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol Chemical Properties,Usage,Production

Uses

Ralaniten (EPI-002) is a potent and orally active antagonist of the androgen receptor-N-terminal domain (AR-NTD). Ralaniten inhibits AR transcriptional activity, with IC50 of 7.4 μM. Ralaniten can be used for the research of castration-resistant prostate cancer (CRPC)[1][2].

in vivo

EPI-002 (100 mg/kg; p.o. twice daily for 28 days) inhibits the VCaP tumor growth in castrated mice^[1].

Animal Model:	Male NOD-SCID mice bearing subcutaneous tumors were castrated
Dosage:	100 mg/kg
Administration:	P.o. twice daily for 28 days
Result:	Inhibited the growth of castration-resistant prostate cancer (CRPC) xenografts that express AR splice variants^[1].

References

[1] Myung JK, et, al. An androgen receptor N-terminal domain antagonist for treating prostate cancer. J Clin Invest. 2013 Jul;123(7):2948-60. DOI:10.1172/JCI66398
[2] Yang YC, et, al. Targeting Androgen Receptor Activation Function-1 with EPI to Overcome Resistance Mechanisms in Castration-Resistant Prostate Cancer. Clin Cancer Res. 2016 Sep 1;22(17):4466-77. DOI:10.1158/1078-0432.CCR-15-2901

(R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol Suppliers

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View Lastest Price from (R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Ralaniten 1203490-23-6
Price: US $3.00-9.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 50kg
Release date: 2025-07-28

1203490-23-6, (R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diolRelated Search:

(R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol

EPI002

1,2-Propanediol, 3-[4-[1-[4-[(2S)-3-chloro-2-hydroxypropoxy]phenyl]-1-methylethyl]phenoxy]-, (2R)-

Ralaniten, 10 mM in DMSO

(R)-3-[4-[1-[4-[(S)-3-Chloro-2-hydroxypropoxy] phenyl]-1-methylethyl]phenoxy]-1,2-propanediol

1203490-23-6