AP39
- Product Name
- AP39
- CAS No.
- 1429173-57-8
- Chemical Name
- AP39
- Synonyms
- AP39;AP39 Free base
- CBNumber
- CB33152549
- Molecular Formula
- C37H38O2PS3+
- Formula Weight
- 641.865
- MOL File
- 1429173-57-8.mol
AP39 Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 5 mg/ml; DMSO: 20 mg/ml; Ethanol: 16 mg/ml; PBS (pH 7.2): 1 mg/ml
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H341Suspected of causing genetic defects
H351Suspected of causing cancer
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P314Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 17100
- Product name
- AP39
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 17100
- Product name
- AP39
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 17100
- Product name
- AP39
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- 17100
- Product name
- AP39
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $533
- Updated
- 2024/03/01
- Product number
- A729260
- Product name
- AP39
- Packaging
- 100mg
- Price
- $1240
- Updated
- 2021/12/16
AP39 Chemical Properties,Usage,Production
Description
AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP39 (30-300 nM) dose-dependently increases H2S levels in endothelial cells, predominantly in mitochondrial regions. It stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an inhibitory effect at 300 nM. Under oxidative stress conditions induced by glucose oxidase, AP39 has antioxidant and cytoprotective effects. AP39 is effective in vivo, inhibiting voltage-dependent T-type calcium channels and improving hemodynamic parameters in rats.
Uses
AP39 is a compound used to increase the level of hydrogen sulphide within the mitochondria because of the presence of the mitochondria targeting motif (triphenylphosphonium). Also used as a photosensitizer, hydrogen sulfide donor, thioredoxin inhibitor or nitroxide combination use in photodynamic therapy.
References
[1] LENKA TOMASOVA . Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels[J]. Nitric oxide: biology and chemistry, 2015, 46: Pages 131-144. DOI: 10.1016/j.niox.2014.12.012
AP39 Preparation Products And Raw materials
Raw materials
Preparation Products
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