CE3F4

Product Name: CE3F4
CAS No.: 143703-25-7
Chemical Name: CE3F4
Synonyms: CE3F4;CE3F4 >=98% (HPLC);CE3F4, 10 mM in DMSO;inhibit,Inhibitor,CE3F4,CE-3F4;5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde;5,7-dibromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline-1-carbaldehyde;1(2H)-Quinolinecarboxaldehyde, 5,7-dibromo-6-fluoro-3,4-dihydro-2-methyl-
CBNumber: CB33152589
Molecular Formula: C11H10Br2FNO
Formula Weight: 351.01
MOL File: 143703-25-7.mol

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CE3F4 Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO > 10 mM
form: Powder
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17767
Product name: CE3F4
Purity: ≥98%
Packaging: 5mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 17767
Product name: CE3F4
Purity: ≥98%
Packaging: 10mg
Price: $146
Updated: 2024/03/01

Cayman Chemical

Product number: 17767
Product name: CE3F4
Purity: ≥98%
Packaging: 50mg
Price: $614
Updated: 2024/03/01

Tocris

Product number: 4793
Product name: CE3F4
Purity: ≥98%(HPLC)
Packaging: 50
Price: $615
Updated: 2021/12/16

Tocris

Product number: 4793
Product name: CE3F4
Purity: ≥98%(HPLC)
Packaging: 10
Price: $149
Updated: 2021/12/16

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CE3F4 Chemical Properties,Usage,Production

Uses

CE3F4 has been used as a selective exchange protein directly activated by cAMP isoform 1 (Epac1) inhibitor in cell proliferation assay to study the influence of Epac type I on cell proliferation of C6 cells (a model of glioma).

Biological Activity

CE3F4 is a tetrahydroquinoline derivative th at blocks agonist-stimulated Epac1 (exchange protein directly activated by cAMP isoform 1) guanine nucleotide exchange activity toward its effector Rap1 (IC50 = 23 μM; Epac agonist = 2 μM 8-CPT-2μ-O-Me-cAMP) by targeting agonist-bound Epac1 in an agonist-uncompetitive manner without affecting the GDP exchange on Rap1, Rap1-Epac1 interaction, or PKA type I/II activity (CβRIβ & CαRIIβ). CE3F4 (20 μM) effectively inhbits cellular Rap1 activation upon 10 μM Sp-8-pCPT-2μ-O-Me-cAMPS (Epac1-transfected HEK293 and r at neonatal cardiac myocytes) or 10 μM β-adrenergic receptor agonist isoprenaline stimulation (β1AR & Epac1 dually transfected HEK293). The isolated CE3F4 R enantiomer is reported to display 10-fold Epac1 selectivity over Epac2, and is 10-times more potent than the CE3F S enantiomer against Epac1.', 'Epac1 is a downstream effector of the cyclic adenosine monophosphate (cAMP) pathway.

storage

Store at -20°C

CE3F4 Preparation Products And Raw materials

Raw materials

Preparation Products

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CE3F4 Suppliers

China 56 United Kingdom 1 United States 8 USA 1 Global 66

Wuhan Acumen Bio-Technology Co.,ltd

Tel: 027-027-16602739303 16602739303
Email: 673003916@qq.com
Country: China
ProdList: 2974
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4589
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
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ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
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Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
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DC Chemicals

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Email: sales@dcchemicals.com
Country: China
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Changzhou Chenhong Biotechnology Co., Ltd.

Tel: 0519-85788828 13775037613
Email: sales@chemrenpharm.com
Country: China
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Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd

Tel: 15317229551
Fax: QQ:3607245178
Email: 15151849396@163.com
Country: China
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ShangHai ChuanQian Chemcial Technique Centre

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143703-25-7, CE3F4Related Search:

CE3F4

5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde

1(2H)-Quinolinecarboxaldehyde, 5,7-dibromo-6-fluoro-3,4-dihydro-2-methyl-

CE3F4 >=98% (HPLC)

inhibit,Inhibitor,CE3F4,CE-3F4

5,7-dibromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline-1-carbaldehyde

CE3F4, 10 mM in DMSO

143703-25-7

C11H10Br2FNO