CE3F4

Product Name: CE3F4
CAS No.: 143703-25-7
Chemical Name: CE3F4
Synonyms: CE3F4;CE3F4 >=98% (HPLC);CE3F4, 10 mM in DMSO;inhibit,Inhibitor,CE3F4,CE-3F4;5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde;5,7-dibromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline-1-carbaldehyde;1(2H)-Quinolinecarboxaldehyde, 5,7-dibromo-6-fluoro-3,4-dihydro-2-methyl-
CBNumber: CB33152589
Molecular Formula: C11H10Br2FNO
Formula Weight: 351.01
MOL File: 143703-25-7.mol

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CE3F4 Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO > 10 mM
form: Powder
color: White to off-white
InChI: InChI=1S/C11H10Br2FNO/c1-6-2-3-7-9(15(6)5-16)4-8(12)11(14)10(7)13/h4-6H,2-3H2,1H3
InChIKey: ZZLQPWXVZCPUGC-UHFFFAOYSA-N
SMILES: N1(C=O)C2=C(C(Br)=C(F)C(Br)=C2)CCC1C

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral
Aquatic Chronic 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2041
Product name: CE3F4
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $85.8
Updated: 2026/03/19

Sigma-Aldrich

Product number: SML2041
Product name: CE3F4
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $347
Updated: 2026/03/19

Cayman Chemical

Product number: 17767
Product name: CE3F4
Purity: ≥98%
Packaging: 5mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 17767
Product name: CE3F4
Purity: ≥98%
Packaging: 10mg
Price: $146
Updated: 2024/03/01

Cayman Chemical

Product number: 17767
Product name: CE3F4
Purity: ≥98%
Packaging: 50mg
Price: $614
Updated: 2024/03/01

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CE3F4 Chemical Properties,Usage,Production

Uses

CE3F4 has been used as a selective exchange protein directly activated by cAMP isoform 1 (Epac1) inhibitor in cell proliferation assay to study the influence of Epac type I on cell proliferation of C6 cells (a model of glioma).

Biological Activity

CE3F4 is a tetrahydroquinoline derivative th at blocks agonist-stimulated Epac1 (exchange protein directly activated by cAMP isoform 1) guanine nucleotide exchange activity toward its effector Rap1 (IC50 = 23 μM; Epac agonist = 2 μM 8-CPT-2μ-O-Me-cAMP) by targeting agonist-bound Epac1 in an agonist-uncompetitive manner without affecting the GDP exchange on Rap1, Rap1-Epac1 interaction, or PKA type I/II activity (CβRIβ & CαRIIβ). CE3F4 (20 μM) effectively inhbits cellular Rap1 activation upon 10 μM Sp-8-pCPT-2μ-O-Me-cAMPS (Epac1-transfected HEK293 and r at neonatal cardiac myocytes) or 10 μM β-adrenergic receptor agonist isoprenaline stimulation (β1AR & Epac1 dually transfected HEK293). The isolated CE3F4 R enantiomer is reported to display 10-fold Epac1 selectivity over Epac2, and is 10-times more potent than the CE3F S enantiomer against Epac1.', 'Epac1 is a downstream effector of the cyclic adenosine monophosphate (cAMP) pathway.

in vivo

CE3F4 (1-3 mg/kg; through a catheter in the internal jugular vein) inhibits atrial fibrillation (AF) and CE3F4 (3 mg/kg; i.v.) inhibits ventricular arrhythmias^[4].
CE3F4 (10 mg/kg; i.v.) improves cardiac function after myocardial infarction in mice^[5].

Animal Model:	Wild-type (WT) mice (induced AF after 20min of CE3F4 administration)^[4]
Dosage:	3 mg/kg and 1mg/kg
Administration:	Through a catheter in the internal jugular vein
Result:	Shortened the duration of the pacing-induced AF at 3mg/kg.

Animal Model:	Casq2-KO mice (premature ventricular contraction induced by isoproterenol injection 20min after CE3F4 administration)^[4]
Dosage:	3 mg/kg
Administration:	I.v.
Result:	Reduced the incidence of sympathetic activation-induced ventricular arrhythmias.

storage

Store at -20°C

CE3F4 Preparation Products And Raw materials

Raw materials

Preparation Products

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CE3F4 Suppliers

China 64 United Kingdom 1 United States 8 USA 1 Global 74

Shanghai Lollane Biological Technology Co.,Ltd.

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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
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Country: China
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ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
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Changzhou Chenhong Biotechnology Co., Ltd.

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ShangHai ChuanQian Chemcial Technique Centre

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MedBioPharmaceutical Technology Inc

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143703-25-7, CE3F4Related Search:

CE3F4

5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde

1(2H)-Quinolinecarboxaldehyde, 5,7-dibromo-6-fluoro-3,4-dihydro-2-methyl-

CE3F4 >=98% (HPLC)

inhibit,Inhibitor,CE3F4,CE-3F4

5,7-dibromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline-1-carbaldehyde

CE3F4, 10 mM in DMSO

143703-25-7

C11H10Br2FNO