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CRANAD 28

Product Name
CRANAD 28
CAS No.
1623747-97-6
Chemical Name
CRANAD 28
Synonyms
CRANAD 28;CRANAD-28, 10 mM in DMSO;CRANAD-28,beta plaques,Inhibitor,CRANAD 28,inhibit;1,7-Bis(5-methyl-1-phenyl-1H-pyrazol-4-yl)hepta-1,6-diene-3,5-dione-difluoroboron;4,4'-((1E,1'E)-(2,2-difluoro-2H-1l3,3,2l4-dioxaborinine-4,6-diyl)bis(ethene-2,1-diyl))bis(5-methyl-1-phenyl-1H-pyrazole);4-[(E)-2-[2,2-difluoro-6-[2-(5-methyl-1-phenylpyrazol-1-ium-4-ylidene)ethylidene]-1,3-dioxa-2-boranuidacyclohex-4-en-4-yl]ethenyl]-5-methyl-1-phenylpyrazole
CBNumber
CB33152594
Molecular Formula
C27H23BF2N4O2
Formula Weight
484.3049264
MOL File
1623747-97-6.mol
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CRANAD 28 Property

storage temp. 
Store at -20°C
solubility 
DMF: 2 mg/ml; DMSO: 2 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
form 
A crystalline solid
color 
Orange to red
InChI
InChI=1S/C27H23BF2N4O2/c1-20-22(18-31-33(20)24-9-5-3-6-10-24)13-15-26-17-27(36-28(29,30)35-26)16-14-23-19-32-34(21(23)2)25-11-7-4-8-12-25/h3-19H,1-2H3
InChIKey
DDFFGVTUEQJYQK-UHFFFAOYSA-N
SMILES
CC1=C(C=NN1C1C=CC=CC=1)C=CC1=O[B+3]([F-])([F-])O=C(C=CC2C=NN(C3C=CC=CC=3)C=2C)[CH-]1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19816
Product name
CRANAD 28
Purity
≥98%
Packaging
500μg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
19816
Product name
CRANAD 28
Purity
≥98%
Packaging
1mg
Price
$61
Updated
2024/03/01
Cayman Chemical
Product number
19816
Product name
CRANAD 28
Purity
≥98%
Packaging
5mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
19816
Product name
CRANAD 28
Purity
≥98%
Packaging
10mg
Price
$426
Updated
2024/03/01
AK Scientific
Product number
SYN5491
Product name
CRANAD-28
Packaging
50mg
Price
$1268
Updated
2021/12/16
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CRANAD 28 Chemical Properties,Usage,Production

Description

CRANAD 28 is a curcumin derivative and non-conjugated fluorescent affinity probe for the detection of amyloid-β (Aβ) in vitro and in vivo that has excitation/emission spectra of 498/578 nm, respectively. It binds to various forms of Aβ, including Aβ40 monomers and aggregates, as well as Aβ42 monomers, dimers, and oligomers (Kds = 68.8, 52.4, 159.7, 162.9, and 85.7 nM, respectively). When bound to Aβ, the fluorescence intensity decreases, in contrast to similar curcumin-based fluorescent probes. CRANAD 28 labels amyloid plaques and cerebral amyloid angiopathy both in APP/PS1 mouse brain sections and in live mice following i.v. administration. It also inhibits copper-induced and naturally occurring Aβ crosslinking.

Uses

CRANAD-28 is a robust fluorescent compound for visualization of amyloid beta plaques[1].

References

[1] Kathleen Ran, et al. CRANAD-28: A Robust Fluorescent Compound for Visualization of Amyloid Beta Plaques. Molecules. 2020 Feb 16;25(4):863. DOI:10.3390/molecules25040863

CRANAD 28 Preparation Products And Raw materials

Raw materials

Preparation Products

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CRANAD 28 Suppliers

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1623747-97-6, CRANAD 28Related Search:


  • 4-[(E)-2-[2,2-difluoro-6-[2-(5-methyl-1-phenylpyrazol-1-ium-4-ylidene)ethylidene]-1,3-dioxa-2-boranuidacyclohex-4-en-4-yl]ethenyl]-5-methyl-1-phenylpyrazole
  • CRANAD 28
  • 1,7-Bis(5-methyl-1-phenyl-1H-pyrazol-4-yl)hepta-1,6-diene-3,5-dione-difluoroboron
  • 4,4'-((1E,1'E)-(2,2-difluoro-2H-1l3,3,2l4-dioxaborinine-4,6-diyl)bis(ethene-2,1-diyl))bis(5-methyl-1-phenyl-1H-pyrazole)
  • CRANAD-28,beta plaques,Inhibitor,CRANAD 28,inhibit
  • CRANAD-28, 10 mM in DMSO
  • 1623747-97-6
  • C27H23BF2N4O2
  • C27H25BF2N4O2