GPR120 Compound A

Product Name: GPR120 Compound A
CAS No.: 1599477-75-4
Chemical Name: GPR120 Compound A
Synonyms: MDK-77754;MDK 77754;GPR120 CPDA;GPR120-IN-1;GPR120 Compound A;GPR120 inhibitor 1;GPR120 COMPOUND A HCl;GPR120 CPDA;GPR120-IN-1;MDK-77754;MDK 77754;3-[2-Chloro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecane-9-acetic acid;3-Azaspiro[5.5]undecane-9-acetic acid, 3-[2-chloro-5-(trifluoromethoxy)phenyl]-
CBNumber: CB33152620
Molecular Formula: C19H23ClF3NO3
Formula Weight: 405.84
MOL File: 1599477-75-4.mol

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GPR120 Compound A Property

Boiling point:: 506.0±50.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
form: crystalline solid
pka: 4.68±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16624
Product name: GPR120 Compound A
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16624
Product name: GPR120 Compound A
Purity: ≥98%
Packaging: 5mg
Price: $131
Updated: 2024/03/01

Cayman Chemical

Product number: 16624
Product name: GPR120 Compound A
Purity: ≥98%
Packaging: 10mg
Price: $214
Updated: 2024/03/01

Cayman Chemical

Product number: 16624
Product name: GPR120 Compound A
Purity: ≥98%
Packaging: 50mg
Price: $759
Updated: 2024/03/01

ApexBio Technology

Product number: C5824
Product name: GPR120CompoundA
Packaging: 50mg
Price: $866
Updated: 2021/12/16

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GPR120 Compound A Chemical Properties,Usage,Production

Biological Activity

gpr120 compound a is an orally active and high-affinity agonist of gpr120 [1].g-protein coupled receptor 120 (gpr120, free fatty acid receptor 4/ffar4) is a g protein-coupled receptor which has been expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids. gpr120 has been involved in mediating the anti-inflammatory and insulin-sensitizing effects of omega 3 fatty acids. deficiency of gpr120 is responsible for reduced fat metabolism, produce anti-inflammatory effects and to acutely potentiate insulin secretion [2].gpr120 compound a activated gpr120 with the ec50 value of ~0.35 μm. gpr120 compound a demonstrated potent selectivity over another lipid-sensing g-protein, gpr40 (ffar1). in a high-fat diet fed obese mice, gpr120 compound a (30 mg/kg) exerted anti-inflammatory effects on macrophages in vitro and improved glucose tolerance, decreased hyperinsulinemia, increased insulin sensitivity, and decreased hepatic steatosis [1].

References

[1] walenta e, akiyama t e, lagakos w s, et al. a gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice[j]. nature medicine, 2014, 20(8): 942-947.
[2] ichimura a, hirasawa a, poulain-godefroy o, et al. dysfunction of lipid sensor gpr120 leads to obesity in both mouse and human[j]. nature, 2012, 483(7389): 350-354.

GPR120 Compound A Preparation Products And Raw materials

Raw materials

Preparation Products

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GPR120 Compound A Suppliers

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View Lastest Price from GPR120 Compound A manufacturers

Career Henan Chemical Co

Product: GPR120 Compound A 1599477-75-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-26

1599477-75-4, GPR120 Compound ARelated Search:

GPR120 Compound A

GPR120-IN-1

GPR120 CPDA;GPR120-IN-1;MDK-77754;MDK 77754

MDK 77754

MDK-77754

GPR120 CPDA

2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5]undecan-9-yl)acetic acid

GPR120 inhibitor 1

GPR120 COMPOUND A HCl

3-Azaspiro[5.5]undecane-9-acetic acid, 3-[2-chloro-5-(trifluoromethoxy)phenyl]-

3-[2-Chloro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecane-9-acetic acid

FFAR,GPR120 Agonist 3,Free Fatty Acid Receptor,inhibit,Inhibitor,GPR-120 Agonist 3

1599477-75-4

C19H23ClF3NO3