ChemicalBook > CAS DataBase List > PKCε Inhibitor Peptide

PKCε Inhibitor Peptide

Product Name: PKCε Inhibitor Peptide
CAS No.: 182683-50-7
Chemical Name: PKCε Inhibitor Peptide
Synonyms: ε-V1-2;epsilonV1-2;KNTBAGOTDJPUJV-XMTFRXHISA-N;L-a-Glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-L-threonine;L-α-Glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-L-threonine;L-Threonine, L-α-glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-
CBNumber: CB33152716
Molecular Formula: C37H65N9O13
Formula Weight: 843.96
MOL File: 182683-50-7.mol

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PKCε Inhibitor Peptide Property

Boiling point:: 1280.1±65.0 °C(Predicted)
Density: 1.288±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 10 mg/ml; PBS (pH 7.2): 5 mg/ml
form: A crystalline solid
pka: 3.28±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17476
Product name: PKCε Inhibitor Peptide
Purity: ≥95%
Packaging: 500μg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17476
Product name: PKCε Inhibitor Peptide
Purity: ≥95%
Packaging: 1mg
Price: $50
Updated: 2024/03/01

Cayman Chemical

Product number: 17476
Product name: PKCε Inhibitor Peptide
Purity: ≥95%
Packaging: 5mg
Price: $230
Updated: 2024/03/01

Cayman Chemical

Product number: 17476
Product name: PKCε Inhibitor Peptide
Purity: ≥95%
Packaging: 10mg
Price: $426
Updated: 2024/03/01

TRC

Product number: G596920
Product name: L-α-Glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-L-threonine
Packaging: 5mg
Price: $195
Updated: 2021/12/16

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PKCε Inhibitor Peptide Chemical Properties,Usage,Production

Uses

L-α-Glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-L-threonine selectively and reversibly inhibits the translocation of PKC? to intracellular membranes, blocking activation. It is a calcium-independent, phospholipid- and diacylglycerol-dependent serine/threonine kinase.

in vivo

Epsilon-V1-2 (20 mg/kg/day; osmotic pumps; daily; for 4 weeks) treatment significantly improves the beating score in a murine heterotopic transplantation model. Epsilon-V1-2 reduces infiltration of macrophages and T cells into the cardiac grafts, and decreases parenchymal fibrosis. Epsilon-V1-2 treatment almost abolishes the rise in pro-fibrotic cytokine, TGF-β and monocyte recruiting chemokine MCP-1 levels^[3].

Animal Model:	C57BL/6J mice transplanted the hearts of FVB mice^[3]
Dosage:	20 mg/kg/day
Administration:	0.1 mL osmotic pumps implanted subcutaneously; daily; for 4 weeks
Result:	Significantly improved the beating score throughout the treatment.

IC 50

PKCε

PKCε Inhibitor Peptide Preparation Products And Raw materials

Raw materials

Preparation Products

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182683-50-7, PKCε Inhibitor PeptideRelated Search:

KNTBAGOTDJPUJV-XMTFRXHISA-N

L-α-Glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-L-threonine

epsilonV1-2

L-a-Glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-L-threonine

L-Threonine, L-α-glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-

ε-V1-2

182683-50-7