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SI-2

Product Name
SI-2
CAS No.
380537-35-9
Chemical Name
SI-2
Synonyms
SI-2;(E)-SI-2;(E)SI2,(E) SI 2;(E)-SI-2, 10 mM in DMSO;1-Methyl-N-[(E)-1-pyridin-2-ylethylideneamino]benzimidazol-2-amine;1-(2-pyridinyl)-, 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone, (1E)-;Ethanone, 1-(2-pyridinyl)-, 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone, (1E)-
CBNumber
CB33152741
Molecular Formula
C15H15N5
Formula Weight
265.313
MOL File
380537-35-9.mol
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SI-2 Property

Boiling point:
459.9±37.0 °C(Predicted)
Density 
1.22±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO (up to 20 mg/ml).
pka
11.05±0.70(Predicted)
form 
solid
color 
Pale orange
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
SMILES
C/C(C1=CC=CC=N1)=N\NC2=NC3=C(C=CC=C3)N2C
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
Hazard Classifications
Eye Irrit. 2
Skin Irrit. 2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1762
Product name
SI-2
Purity
≥98% (HPLC)
Packaging
25MG
Price
$434
Updated
2026/03/19
Sigma-Aldrich
Product number
SML1762
Product name
SI-2
Purity
≥98% (HPLC)
Packaging
5MG
Price
$99.5
Updated
2025/07/31
Cayman Chemical
Product number
19565
Product name
SI-2
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
19565
Product name
SI-2
Purity
≥98%
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
19565
Product name
SI-2
Purity
≥98%
Packaging
10mg
Price
$299
Updated
2024/03/01
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SI-2 Chemical Properties,Usage,Production

Description

SI-2 (380537-35-9) is a potent inhibitor of steroid receptor coactivator-3 (SRC-3).1It blocks MDA-MB-468 cell growth with an IC50= 3.4 nM without effecting normal cells.1It significantly inhibited breast cancer cell growth in an orthotopic MDA-MD-468 mouse model. Treatment of MCF-7 or triple negative MDA-MB-231 cells with SI-2 resulted in inhibition of proliferation and breast cancer stem cell (CSC) tumorsphere formation.2CSC markers CD44+/CD24-/1oand aldehyde dehydrogenase (ALDH) were also reduced indicating that SI-2 can selectively interfere with the TIC/CSC state in breast cancer cells.2,3

Uses

SI-2 is an inhibitor of steroid receptor coactivator-3 (SRC-3). Induces cell death in verious breast cancer cells.

Biochem/physiol Actions

SI-2 targets the receptor-interacting domain (RID) of steroid receptor coactivators (SRCs) and suppresses cellular transcriptional activity (Effec. conc. >/= 5 nM in cell-based SRC-1, SRC-2, and SRC-3 reporter assays) by downregulating SRCs protein, but not transcript level (Effec. conc. >/= 12.5 nM against SRC-3, >/= 25 nM against SRC-1 and SCR-2 in MDA-MB-468 culture). SI-2 is cytotoxic to breast cancer cultures (IC50= 1.5 nM/BT-474, 3.4 nM/MDA-MB-468, 22 nM/MCF-7), but not to normal hepatocytes even at 500 nM concentration. SI-2 is reported to be orally available in mice and, when administered intraperitoneally (2 mg/kg b.i.d.), effectively suppress MDA-MB-468-derived tumor expansion in micein vivowith good pharmacokinetics (Cmax= 30 μM,tmax= 0.25 h,t1/2= 1.0 h; 20 mg/kg i.p.) and no apparent adverse effects to the animals.

References

[1] XIANZHOU SONG. Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 18: 4970-4975. DOI:10.1073/pnas.1604274113
[2] AARTI D ROHIRA. Targeting SRC Coactivators Blocks the Tumor-Initiating Capacity of Cancer Stem-like Cells.[J]. Cancer research, 2017, 77 16: 4293-4304. DOI:10.1158/0008-5472.can-16-2982
[3] THU H TRUONG. Cancer Stem Cell Phenotypes in ER+ Breast Cancer Models Are Promoted by PELP1/AIB1 Complexes.[J]. Molecular Cancer Research, 2018, 16 4: 707-719. DOI:10.1158/1541-7786.mcr-17-0598

SI-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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SI-2 Suppliers

China 34 United States 5 Global 39
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30227
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24960
Advantage
58
Suzhou Zhixin Biotechnology Co., Ltd.
Tel
0512-65118909 18100677375
Email
sales@szzxbio.com
Country
China
ProdList
3000
Advantage
58

380537-35-9, SI-2Related Search:

Ko 143 Adapalene Cantharidin Troglitazone

  • SI-2
  • Ethanone, 1-(2-pyridinyl)-, 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone, (1E)-
  • 1-(2-pyridinyl)-, 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone, (1E)-
  • (E)-SI-2
  • (E)SI2,(E) SI 2
  • (E)-SI-2, 10 mM in DMSO
  • 1-Methyl-N-[(E)-1-pyridin-2-ylethylideneamino]benzimidazol-2-amine
  • 380537-35-9