ChemicalBook > CAS DataBase List > BAR 501

BAR 501

Product Name: BAR 501
CAS No.: 1632118-69-4
Chemical Name: BAR 501
Synonyms: BAR 501;CPDD0945;BAR 501; BAR-501;BAR501, 10 mM in DMSO;Cholane-3,7,24-triol, 6-ethyl-, (3α,5β,6β,7β)-;BAR501, 98%, a potent and selective agonist of GPBAR1;Inhibitor,GPBAR1,TGR5,GPCR19,G-protein coupled receptor 19,BAR-501,BAR501,G protein-coupled Bile Acid Receptor 1,inhibit;(3R,5S,6S,7S,8S,9S,10S,13R,14S,17R)-6-ethyl-17-((R)-5-hydroxypentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol
CBNumber: CB33153036
Molecular Formula: C26H46O3
Formula Weight: 406.64
MOL File: 1632118-69-4.mol

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BAR 501 Property

Boiling point:: 527.6±25.0 °C(Predicted)
Density: 1.047±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:65.5(Max Conc. mg/mL);161.07(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);49.18(Max Conc. mM)
Ethanol:34.33(Max Conc. mg/mL);84.42(Max Conc. mM)
form: A crystalline solid
pka: 14.82±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22460
Product name: BAR501
Purity: ≥95%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 22460
Product name: BAR501
Purity: ≥95%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 22460
Product name: BAR501
Purity: ≥95%
Packaging: 10mg
Price: $283
Updated: 2024/03/01

Cayman Chemical

Product number: 22460
Product name: BAR501
Purity: ≥95%
Packaging: 25mg
Price: $618
Updated: 2024/03/01

Biosynth Carbosynth

Product number: BB178048
Product name: BAR-501
Packaging: 25mg
Price: $700
Updated: 2021/12/16

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BAR 501 Chemical Properties,Usage,Production

Uses

BAR501 is a potent and selective agonist of GPBAR1 with an EC50 of 1 μM.

in vivo

Pretreating rats for 6 days with BAR501, 15 mg/kg, reduces basal portal pressure and blunts the vasoconstriction activity of norepinephrine. Pretreatment with BAR501 attenuates the hepatic vasomotor activity induced by shear stress and methoxamine. Administration of BAR501 exerts a direct vasodilatory activity in the CCl4 model. Treating mice with BAR501 at the dose of 15 mg/Kg reduces portal pressure and AST plasma levels. BAR501 attenuates endothelial dysfunction by regulating CSE expression/activity^[1].

References

[1] Renga B, et al. Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H2S Generation and Endothelin-1. PLoS One. 2015 Nov 5;10(11):e0141082. DOI:10.1371/journal.pone.0141082

BAR 501 Preparation Products And Raw materials

Raw materials

Preparation Products

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1632118-69-4, BAR 501Related Search:

BAR 501

CPDD0945

BAR501, 98%, a potent and selective agonist of GPBAR1

BAR 501; BAR-501

(3R,5S,6S,7S,8S,9S,10S,13R,14S,17R)-6-ethyl-17-((R)-5-hydroxypentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol

Inhibitor,GPBAR1,TGR5,GPCR19,G-protein coupled receptor 19,BAR-501,BAR501,G protein-coupled Bile Acid Receptor 1,inhibit

Cholane-3,7,24-triol, 6-ethyl-, (3α,5β,6β,7β)-

BAR501, 10 mM in DMSO

1632118-69-4

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