BMT-145027
- Product Name
- BMT-145027
- CAS No.
- 2018282-44-3
- Chemical Name
- BMT-145027
- Synonyms
- BMT-145027;BMT145027;BMT 145027;Inhibitor,mGluR,inhibit,BMT-145027,BMT145027,BMT 145027,Metabotropic glutamate receptors;3-[4-chloro-3-(trifluoromethyl)phenyl]-4-cyclopropyl-6-phenyl-2H-pyrazolo[3,4-b]pyridine-5-carbonitrile;1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile, 3-[4-chloro-3-(trifluoromethyl)phenyl]-4-cyclopropyl-6-phenyl-
- CBNumber
- CB33153223
- Molecular Formula
- C23H14ClF3N4
- Formula Weight
- 438.83
- MOL File
- 2018282-44-3.mol
BMT-145027 Property
- Boiling point:
- 653.2±55.0 °C(Predicted)
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 2.4 mg/mL (5.47 mM)
- pka
- 7.40±0.40(Predicted)
- form
- Solid
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- CS-6911
- Product name
- BMT-145027
- Purity
- 98.19%
- Packaging
- 5mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- CS-6911
- Product name
- BMT-145027
- Purity
- 98.19%
- Packaging
- 10mg
- Price
- $410
- Updated
- 2021/12/16
- Product number
- CS-6911
- Product name
- BMT-145027
- Purity
- 98.19%
- Packaging
- 50mg
- Price
- $1200
- Updated
- 2021/12/16
- Product number
- DC9937
- Product name
- BMT-145027
- Purity
- >98%
- Packaging
- 1g
- Price
- $2300
- Updated
- 2021/12/16
- Product number
- DC9937
- Product name
- BMT-145027
- Purity
- >98%
- Packaging
- 100mg
- Price
- $650
- Updated
- 2021/12/16
BMT-145027 Chemical Properties,Usage,Production
Uses
BMT-145027 is an mGluR5 positive allosteric modulator without inherent agonist activity, exhibits an EC50 of 47 nM.
in vivo
Drug-treated and control mice are shown two identical objects. After a 24-h natural forgetting period, the mice are reintroduced to a familiar object while simultaneously presented with a novel object. Since mice spend more time exploring unfamiliar objects, improved memory is measured as time spent exploring the novel object. BMT-145027 leads to a significant increase in time spent with the novel object when dosed at 30 mg/kg, with an apparent trend in novel object preference at 10 mg/kg. Satellite animals indicates a total plasma concentration of 2800 nM at 30 mg/kg[1].
IC 50
mGluR5: 47 nM (EC50)
References
[1] Hill MD, et al. Development of 1H-Pyrazolo[3,4-b]pyridines as Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators. ACS Med Chem Lett. 2016 Oct 3;7(12):1082-1086. DOI:10.1021/acsmedchemlett.6b00292
BMT-145027 Preparation Products And Raw materials
Raw materials
Preparation Products
BMT-145027 Suppliers
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