ChemicalBook > CAS DataBase List > ADU-S100 ammonium salt

ADU-S100 ammonium salt

Product Name: ADU-S100 ammonium salt
CAS No.: 1638750-96-5
Chemical Name: ADU-S100 ammonium salt
Synonyms: MIW815 ammonium salt;ADU-S100 ammonium salt;ML RR-S2 CDA (ammonium salt);STING-INDUCER-1 AMMONIUM SALT;ML RR-S2 CDA ammonium salt(ADU-S100);ADU-S100 ammonium salt, 10 mM in DMSO;Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide, ammonium salt (1:2);inhibit,ADU S100 ammonium salt,TMEM173,STING,MIW815,Inhibitor,MIW-815,Stimulator of Interferon Genes,MITA,MPYS,ERIS,ADU-S100,ML RR-S2 CDA,MIW 815,ADUS100 ammonium salt
CBNumber: CB33155065
Molecular Formula: C20H27N11O10P2S2
Formula Weight: 707.57
MOL File: 1638750-96-5.mol

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ADU-S100 ammonium salt Property

storage temp.: Store at -20°C
solubility: DMSO: 15 mg/ml; Water: 12.5 mg/ml
form: A solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 24106
Product name: ML RR-S2 CDA (ammonium salt)
Purity: ≥98%
Packaging: 500μg
Price: $778
Updated: 2024/03/01

Cayman Chemical

Product number: 24106
Product name: ML RR-S2 CDA (ammonium salt)
Purity: ≥98%
Packaging: 1mg
Price: $1164
Updated: 2024/03/01

ChemScene

Product number: CS-6093
Product name: ADU-S100ammoniumsalt
Purity: 99.44%
Packaging: 1mg
Price: $195
Updated: 2021/12/16

ChemScene

Product number: CS-6093
Product name: ADU-S100ammoniumsalt
Purity: 99.44%
Packaging: 5mg
Price: $645
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611556
Product name: ML RR-S2 CDA ammonium salt
Purity: >98%
Packaging: 5mg
Price: $765
Updated: 2021/12/16

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ADU-S100 ammonium salt Chemical Properties,Usage,Production

Description

ML RR-S2 CDA is a synthetic cyclic dinucleotide (CDN) that contains non-canonical 2''5''-phosphodiester bonds and is an activator of stimulator of interferon genes (STING). It contains mixed linkages (ML) with both 2''5'' and 3''5'' linkages, which leads to increased thermal stability of human STING in a differential scanning fluorimetry (DSF) assay. ML RR-S2 CDA increases type I interferon production by THP-1 human monocytes relative to unmodified cyclic di-AMP (CDA; ), indicating the ML enhances its action at human STING. It induces expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and Mcp-1 in murine bone marrow macrophages (BMM) isolated from wild-type, but not STING^-/-, mice. ML RR-S2 CDA also induces IFN-β expression in peripheral blood mononuclear cells (PBMCs) isolated from donors carrying STING^WT/WT, STING^WT/REF, and STING^WT/HAQ alleles. In vivo, ML RR-S2 CDA initiates tumor regression and prevents tumor growth upon tumor cell reimplantation in 4T1 murine mammary and CT26 murine colon cancer models.

Uses

2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt (ADU-S100 ammonium salt), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity[1].

in vivo

2’3’-c-di-AM(PS)2 (Rp,Rp) shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the 2’3’-c-di-AM(PS)2 (Rp,Rp) compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8⁺ T cell responses, and improves long-term survival to 50%^[1].

References

[1] Corrales L, et al. Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity. Cell Rep. 2015 May 19;11(7):1018-30. DOI:10.1016/j.celrep.2015.04.031

ADU-S100 ammonium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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1638750-96-5, ADU-S100 ammonium saltRelated Search:

Ammonia

ML RR-S2 CDA (ammonium salt)

Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide, ammonium salt (1:2)

ADU-S100 ammonium salt

STING-INDUCER-1 AMMONIUM SALT

MIW815 ammonium salt

ML RR-S2 CDA ammonium salt(ADU-S100)

inhibit,ADU S100 ammonium salt,TMEM173,STING,MIW815,Inhibitor,MIW-815,Stimulator of Interferon Genes,MITA,MPYS,ERIS,ADU-S100,ML RR-S2 CDA,MIW 815,ADUS100 ammonium salt

ADU-S100 ammonium salt, 10 mM in DMSO

1638750-96-5