BAR 502
- Product Name
- BAR 502
- CAS No.
- 1612191-86-2
- Chemical Name
- BAR 502
- Synonyms
- 181945;BAR 502;BAR502 ，S0033;CID 101886309;BAR 502;BAR-502;BAR502;BAR 502, 98%, a dual FXR and GPBAR1 agonist;6α-ethyl-3α,7α-dihydroxy-24-nor-5β-cholan-23-ol;24-Norcholane-3,7,23-triol, 6-ethyl-, (3α,5β,6α,7α)-;(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-17-((R)-4-hydroxybutan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol;GPCR19,BAR 502,G protein-coupled Bile Acid Receptor 1,BAR-502,BAR502,Autophagy,GPBAR1,NR1H4,Inhibitor,G-protein coupled receptor 19,inhibit,FXR,TGR5
- CBNumber
- CB33155146
- Molecular Formula
- C25H44O3
- Formula Weight
- 392.62
- MOL File
- 1612191-86-2.mol
BAR 502 Property
- Boiling point:
- 516.0±25.0 °C(Predicted)
- Density
- 1.055±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:35.0(Max Conc. mg/mL);89.14(Max Conc. mM)
Ethanol:51.0(Max Conc. mg/mL);129.89(Max Conc. mM) - form
- A crystalline solid
- pka
- 14.81±0.70(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 22462
- Product name
- BAR502
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 22462
- Product name
- BAR502
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $143
- Updated
- 2024/03/01
- Product number
- 22462
- Product name
- BAR502
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $254
- Updated
- 2024/03/01
- Product number
- 22462
- Product name
- BAR502
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $553
- Updated
- 2024/03/01
- Product number
- CS-6892
- Product name
- BAR502
- Purity
- >98.0%
- Packaging
- 1mg
- Price
- $132
- Updated
- 2021/12/16
BAR 502 Chemical Properties,Usage,Production
Uses
BAR-502 3-O-Sulfate is an impurity of BAR-502 (B161220), which can be used to treat hepatitis D virus infection.
in vivo
Treatment with BAR502 causes a 10% reduction of b.w., increases insulin sensitivity and circulating levels of HDL, while reduces steatosis, inflammatory and fibrosis scores and liver expression of SREPB1c, FAS, PPARγ, CD36 and CYP7A1 mRNA. BAR502 increases the expression of SHP and ABCG5 in the liver and SHP, FGF15 and GLP1 in intestine. BAR502 promotes the browning of epWAT and reduces liver fibrosis induced by CCl4[2]. In models of non-obstructive cholestasis, BAR502 attenuates liver injury without causing itching. Co-treatment with BAR502 increases survival, attenuates serum alkaline phosphatase levels and robustly modulates the liver expression of canonical FXR target genes including OSTα, BSEP, SHP and MDR1, without inducing pruritus[3].
BAR 502 Preparation Products And Raw materials
Raw materials
Preparation Products
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