ChemicalBook > CAS DataBase List > BAR 502

BAR 502

Product Name: BAR 502
CAS No.: 1612191-86-2
Chemical Name: BAR 502
Synonyms: 181945;BAR 502;BAR502 ，S0033;CID 101886309;BAR 502;BAR-502;BAR502;BAR 502, 98%, a dual FXR and GPBAR1 agonist;6α-ethyl-3α,7α-dihydroxy-24-nor-5β-cholan-23-ol;24-Norcholane-3,7,23-triol, 6-ethyl-, (3α,5β,6α,7α)-;(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-17-((R)-4-hydroxybutan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol;GPCR19,BAR 502,G protein-coupled Bile Acid Receptor 1,BAR-502,BAR502,Autophagy,GPBAR1,NR1H4,Inhibitor,G-protein coupled receptor 19,inhibit,FXR,TGR5
CBNumber: CB33155146
Molecular Formula: C25H44O3
Formula Weight: 392.62
MOL File: 1612191-86-2.mol

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BAR 502 Property

Boiling point:: 516.0±25.0 °C(Predicted)
Density: 1.055±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:35.0(Max Conc. mg/mL);89.14(Max Conc. mM)
Ethanol:51.0(Max Conc. mg/mL);129.89(Max Conc. mM)
form: A crystalline solid
pka: 14.81±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22462
Product name: BAR502
Purity: ≥95%
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 22462
Product name: BAR502
Purity: ≥95%
Packaging: 5mg
Price: $143
Updated: 2024/03/01

Cayman Chemical

Product number: 22462
Product name: BAR502
Purity: ≥95%
Packaging: 10mg
Price: $254
Updated: 2024/03/01

Cayman Chemical

Product number: 22462
Product name: BAR502
Purity: ≥95%
Packaging: 25mg
Price: $553
Updated: 2024/03/01

ChemScene

Product number: CS-6892
Product name: BAR502
Purity: >98.0%
Packaging: 1mg
Price: $132
Updated: 2021/12/16

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BAR 502 Chemical Properties,Usage,Production

Uses

BAR-502 3-O-Sulfate is an impurity of BAR-502 (B161220), which can be used to treat hepatitis D virus infection.

in vivo

Treatment with BAR502 causes a 10% reduction of b.w., increases insulin sensitivity and circulating levels of HDL, while reduces steatosis, inflammatory and fibrosis scores and liver expression of SREPB1c, FAS, PPARγ, CD36 and CYP7A1 mRNA. BAR502 increases the expression of SHP and ABCG5 in the liver and SHP, FGF15 and GLP1 in intestine. BAR502 promotes the browning of epWAT and reduces liver fibrosis induced by CCl4^[2]. In models of non-obstructive cholestasis, BAR502 attenuates liver injury without causing itching. Co-treatment with BAR502 increases survival, attenuates serum alkaline phosphatase levels and robustly modulates the liver expression of canonical FXR target genes including OSTα, BSEP, SHP and MDR1, without inducing pruritus^[3].

BAR 502 Preparation Products And Raw materials

Raw materials

Preparation Products

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1612191-86-2, BAR 502Related Search:

(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-17-((R)-4-hydroxybutan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol

6α-ethyl-3α,7α-dihydroxy-24-nor-5β-cholan-23-ol

BAR 502

BAR 502, 98%, a dual FXR and GPBAR1 agonist

181945

24-Norcholane-3,7,23-triol, 6-ethyl-, (3α,5β,6α,7α)-

BAR 502;BAR-502;BAR502

GPCR19,BAR 502,G protein-coupled Bile Acid Receptor 1,BAR-502,BAR502,Autophagy,GPBAR1,NR1H4,Inhibitor,G-protein coupled receptor 19,inhibit,FXR,TGR5

CID 101886309

BAR502 ，S0033

1612191-86-2