Abediterol

Product Name: Abediterol
CAS No.: 1262414-04-9
Chemical Name: Abediterol
Synonyms: ACT-334441;CS-2487;Abediterol;Cenerimod/ACT-334441;ACT-334441; ACT334441; ACT 334441;(S)-3-(4-(5-(2-CYCLOPENTYL-6-METHOXYPYRIDIN-4-YL)-1,2,4-OXADIAZOL-3-YL)-2-ETHYL-6-METHYLPHENOXY)PROPANE-1,2-DIOL;1,2-Propanediol, 3-[4-[5-(2-cyclopentyl-6-methoxy-4-pyridinyl)-1,2,4-oxadiazol-3-yl]-2-ethyl-6-methylphenoxy]-, (2S)-
CBNumber: CB33159856
Molecular Formula: C25H31N3O5
Formula Weight: 453.53
MOL File: 1262414-04-9.mol

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Abediterol Property

Boiling point:: 670.7±65.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:100.0(Max Conc. mg/mL);220.49(Max Conc. mM)
form: A crystalline solid
pka: 13.44±0.20(Predicted)
color: White to yellow
InChIKey: KJKKMMMRWISKRF-FQEVSTJZSA-N
SMILES: C(O)[C@H](O)COC1=C(C)C=C(C2N=C(C3C=C(OC)N=C(C4CCCC4)C=3)ON=2)C=C1CC

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29665
Product name: Cenerimod
Packaging: 5mg
Price: $72
Updated: 2024/03/01

Cayman Chemical

Product number: 29665
Product name: Cenerimod
Packaging: 25mg
Price: $301
Updated: 2024/03/01

Cayman Chemical

Product number: 29665
Product name: Cenerimod
Packaging: 10mg
Price: $135
Updated: 2024/03/01

ChemScene

Product number: CS-6364
Product name: Cenerimod
Purity: 98.02%
Packaging: 2mg
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: 3599DH
Product name: Cenerimod
Packaging: 10mg
Price: $248
Updated: 2021/12/16

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Abediterol Chemical Properties,Usage,Production

Uses

Cenerimod (ACT-334441) is a potent, selective and orally active S1P1 receptor modulator, with an EC50 of 1 nM. Cenerimod shows more than 36 fold selctivity for hS1P1 over hS1P2, hS1P3, hS1P4, and hS1P5 receptor subtypes (EC50s=>10000, 228, 2134, and 36 nM, respectively). Cenerimod can attenuate murine experimental autoimmune encephalomyelitis (EAE) and murine sclerodermatous[1][2].

in vivo

Cenerimod (0.1-10 mg/kg; a single p.o.) reversibly reduces the number of circulating lymphocytes in a dose-dependent manner in rats^[1].
Cenerimod (6 mg/kg/day for 30 days; p.o.) attenuates disease in a mouse experimental autoimmune encephalitis (EAE) model^[1].
Cenerimod (10 mg/kg/day for 42 days; p.o.) attenuates skin and lung fibrosis in Scl-cGVHD mice^[2].

Animal Model:	Male Wistar rats weighing 294-510 g^[1]
Dosage:	0.1, 0.3, 1, 3 and 10 mg/kg
Administration:	A single p.o.
Result:	Effectively and reversibly reduced the blood lymphocyte counts, with a plateau reached after a single oral dose of 1 mg/kg.

IC 50

S1PR1: 1 nM (EC₅₀); S1PR5: 36 nM (EC₅₀); S1PR5: 228 nM (EC₅₀); S1PR4: 2134 nM (EC₅₀)

References

[1] Piali L, et, al. Cenerimod, a novel selective S1P 1 receptor modulator with unique signaling properties. Pharmacol Res Perspect. 2017 Dec;5(6):e00370. DOI:10.1002/prp2.370
[2] Kano M, et, al. Attenuation of murine sclerodermatous models by the selective S1P 1 receptor modulator cenerimod. Sci Rep. 2019 Jan 24;9(1):658. DOI:10.1038/s41598-018-37074-9

Abediterol Preparation Products And Raw materials

Raw materials

Preparation Products

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Abediterol Suppliers

China 48 United States 8 Global 56

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

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Bayee Biotech (Anqing) Co., Ltd.

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BOC Sciences

Tel: 1-631-485-4226; 16314854226
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ShangHai Caerulum Pharma Discovery Co., Ltd.

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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
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Tianjin Kailiqi Biotechnology Co., Ltd.

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ShangHai Biochempartner Co.,Ltd

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Shanghai Chaolan Chemical Technology Center

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Amadis Chemical Company Limited

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1262414-04-9, AbediterolRelated Search:

Abediterol

ACT-334441

(S)-3-(4-(5-(2-CYCLOPENTYL-6-METHOXYPYRIDIN-4-YL)-1,2,4-OXADIAZOL-3-YL)-2-ETHYL-6-METHYLPHENOXY)PROPANE-1,2-DIOL

CS-2487

ACT-334441; ACT334441; ACT 334441

1,2-Propanediol, 3-[4-[5-(2-cyclopentyl-6-methoxy-4-pyridinyl)-1,2,4-oxadiazol-3-yl]-2-ethyl-6-methylphenoxy]-, (2S)-

Cenerimod/ACT-334441

1262414-04-9

APIS