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Abediterol

Product Name
Abediterol
CAS No.
1262414-04-9
Chemical Name
Abediterol
Synonyms
ACT-334441;CS-2487;Abediterol;Cenerimod/ACT-334441;ACT-334441; ACT334441; ACT 334441;(S)-3-(4-(5-(2-CYCLOPENTYL-6-METHOXYPYRIDIN-4-YL)-1,2,4-OXADIAZOL-3-YL)-2-ETHYL-6-METHYLPHENOXY)PROPANE-1,2-DIOL;1,2-Propanediol, 3-[4-[5-(2-cyclopentyl-6-methoxy-4-pyridinyl)-1,2,4-oxadiazol-3-yl]-2-ethyl-6-methylphenoxy]-, (2S)-
CBNumber
CB33159856
Molecular Formula
C25H31N3O5
Formula Weight
453.53
MOL File
1262414-04-9.mol
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Abediterol Property

Boiling point:
670.7±65.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:100.0(Max Conc. mg/mL);220.49(Max Conc. mM)
form 
A crystalline solid
pka
13.44±0.20(Predicted)
color 
White to yellow
InChIKey
KJKKMMMRWISKRF-FQEVSTJZSA-N
SMILES
C(O)[C@H](O)COC1=C(C)C=C(C2N=C(C3C=C(OC)N=C(C4CCCC4)C=3)ON=2)C=C1CC
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29665
Product name
Cenerimod
Packaging
5mg
Price
$72
Updated
2024/03/01
Cayman Chemical
Product number
29665
Product name
Cenerimod
Packaging
25mg
Price
$301
Updated
2024/03/01
Cayman Chemical
Product number
29665
Product name
Cenerimod
Packaging
10mg
Price
$135
Updated
2024/03/01
AK Scientific
Product number
3599DH
Product name
Cenerimod
Packaging
10mg
Price
$248
Updated
2021/12/16
ChemScene
Product number
CS-6364
Product name
Cenerimod
Purity
98.02%
Packaging
2mg
Price
$50
Updated
2021/12/16
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Abediterol Chemical Properties,Usage,Production

Uses

Cenerimod (ACT-334441) is a potent, selective and orally active S1P1 receptor modulator, with an EC50 of 1 nM. Cenerimod shows more than 36 fold selctivity for hS1P1 over hS1P2, hS1P3, hS1P4, and hS1P5 receptor subtypes (EC50s=>10000, 228, 2134, and 36 nM, respectively). Cenerimod can attenuate murine experimental autoimmune encephalomyelitis (EAE) and murine sclerodermatous[1][2].

in vivo

Cenerimod (0.1-10 mg/kg; a single p.o.) reversibly reduces the number of circulating lymphocytes in a dose-dependent manner in rats[1].
Cenerimod (6 mg/kg/day for 30 days; p.o.) attenuates disease in a mouse experimental autoimmune encephalitis (EAE) model[1].
Cenerimod (10 mg/kg/day for 42 days; p.o.) attenuates skin and lung fibrosis in Scl-cGVHD mice[2].

Animal Model:Male Wistar rats weighing 294-510 g[1]
Dosage:0.1, 0.3, 1, 3 and 10 mg/kg
Administration:A single p.o.
Result:Effectively and reversibly reduced the blood lymphocyte counts, with a plateau reached after a single oral dose of 1 mg/kg.

IC 50

S1PR1: 1 nM (EC50); S1PR5: 36 nM (EC50); S1PR5: 228 nM (EC50); S1PR4: 2134 nM (EC50)

References

[1] Piali L, et, al. Cenerimod, a novel selective S1P 1 receptor modulator with unique signaling properties. Pharmacol Res Perspect. 2017 Dec;5(6):e00370. DOI:10.1002/prp2.370
[2] Kano M, et, al. Attenuation of murine sclerodermatous models by the selective S1P 1 receptor modulator cenerimod. Sci Rep. 2019 Jan 24;9(1):658. DOI:10.1038/s41598-018-37074-9

Abediterol Preparation Products And Raw materials

Raw materials

Preparation Products

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Abediterol Suppliers

China 48 United States 8 Global 56
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

1262414-04-9, AbediterolRelated Search:


  • Abediterol
  • ACT-334441
  • (S)-3-(4-(5-(2-CYCLOPENTYL-6-METHOXYPYRIDIN-4-YL)-1,2,4-OXADIAZOL-3-YL)-2-ETHYL-6-METHYLPHENOXY)PROPANE-1,2-DIOL
  • CS-2487
  • ACT-334441; ACT334441; ACT 334441
  • 1,2-Propanediol, 3-[4-[5-(2-cyclopentyl-6-methoxy-4-pyridinyl)-1,2,4-oxadiazol-3-yl]-2-ethyl-6-methylphenoxy]-, (2S)-
  • Cenerimod/ACT-334441
  • 1262414-04-9
  • APIS