ChemicalBook > CAS DataBase List > Esaxerenone

Esaxerenone

Product Name: Esaxerenone
CAS No.: 1632006-28-0
Chemical Name: Esaxerenone
Synonyms: cs3150;cs-3150;CS-2614;XL-550);Esaxerenone;5G,100G,500G;Esaxerenone(CS-3150);CS-3150 (Esaxerenone;Esaxerenone, 10 mM in DMSO;CS-3150; CS 3150; CS3150; XL-550; XL550; XL 550.
CBNumber: CB33159937
Molecular Formula: C22H21F3N2O4S
Formula Weight: 466.48
MOL File: 1632006-28-0.mol

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Esaxerenone Property

Boiling point:: 581.3±50.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
solubility: DMSO:100.0(Max Conc. mg/mL);214.37(Max Conc. mM)
pka: 12.76±0.70(Predicted)
form: Solid
color: White to light yellow
InChI: InChI=1S/C22H21F3N2O4S/c1-14-18(21(29)26-15-7-9-16(10-8-15)32(2,30)31)13-27(11-12-28)20(14)17-5-3-4-6-19(17)22(23,24)25/h3-10,13,28H,11-12H2,1-2H3,(H,26,29)
InChIKey: NOSNHVJANRODGR-UHFFFAOYSA-N
SMILES: C(N1C=C(C(=O)NC2C=CC(S(=O)(=O)C)=CC=2)C(C)=C1C1C=CC=CC=1C(F)(F)F)CO

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: E888295
Product name: Esaxerenone
Packaging: 10mg
Price: $270
Updated: 2021/12/16

ChemScene

Product number: CS-8044
Product name: Esaxerenone
Purity: 99.84%
Packaging: 1mg
Price: $132
Updated: 2021/12/16

ChemScene

Product number: CS-8044
Product name: Esaxerenone
Purity: 99.84%
Packaging: 5mg
Price: $396
Updated: 2021/12/16

ChemScene

Product number: CS-8044
Product name: Esaxerenone
Purity: 99.84%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-8044
Product name: Esaxerenone
Purity: 99.84%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

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Esaxerenone Chemical Properties,Usage,Production

Uses

Esaxerenone, is a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist.

Biological Activity

Esaxerenone exerts its antihypertensive effect by blocking excessive activation of the mineralocorticoid receptor by endogenous ligands (such as aldosterone), has a mineralocorticoid receptor selectivity at least 1000-fold greater than other steroid hormone receptors, a long half-life, high oral bioavailability, and has a more significant antihypertensive effect than spironolactone or eplerenone.

Synthesis

below shows the synthesis route of Esaxerenone

in vivo

After single oral administration of Esaxerenone at 0.1, 0.3, 1, and 3?mg/kg, maximum plasma concentration (C_max) and the area under the plasma concentration versus time curve (AUC) are increased with dose. Time to reach the maximum plasma concentration (T_max) of Esaxerenone ranges from 2.0 to 4.5?h. After intravenous administration of Esaxerenone at 0.1, 0.3, 1, and 3?mg/kg, the total body clearance (CL) and distribution volume at steady state (V_ss) are 3.53 to 6.69?mL/min/kg and 1.47 to 2.49?L/kg, respectively, in rats, and 2.79 to 3.69?mL/min/kg and 1.34 to 1.54?L/kg, respectively, in cynomolgus monkeys. Up to 168?h after administration, 3.9% and 91.4% of dosed radioactivity are excreted in rat urine and feces, respectively, and 95.2% in total. In monkeys, the excreted radioactivity up to 168?h is 11.5% in urine, 82.3% in feces, and 93.9% in total^[1].

Esaxerenone Preparation Products And Raw materials

Raw materials

Preparation Products

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Esaxerenone Suppliers

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View Lastest Price from Esaxerenone manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Esaxerenone 1632006-28-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-07

1632006-28-0, EsaxerenoneRelated Search:

cs3150

cs-3150

Esaxerenone

CS-3150 (Esaxerenone

XL-550)

CS-2614

5G,100G,500G

CS-3150; CS 3150; CS3150; XL-550; XL550; XL 550.

1H-Pyrrole-3-carboxamide, 1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-, (5S)-

1-(2-hydroxyethyl)-4-methyl-N-(4-methylsulfonylphenyl)-5-[2-(trifluoromethyl)phenyl]pyrrole-3-carboxamide

Esaxerenone(CS-3150)

Esaxerenone,Inhibitor,Mineralocorticoid Receptor,CS 3150,CS3150,inhibit,XL550,XL 550

1-(2-Hydroxyethyl)-4-methyl-N-(4-(methylsulfonyl)phenyl)-5-(2-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide

Esaxerenone, 10 mM in DMSO

1-(2-Hydroxyethyl)-4-methyl-N-(4-(methylsulfonyl)phenyl)-5-(2-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide , Esaxerenone

(5P)-1-(2-Hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2- (trifluoromethyl) phenyl]-1H-pyrrole-3-carboxamide

1632006-28-0