Setmelanotide
- Product Name
- Setmelanotide
- CAS No.
- 1294000-61-5
- Chemical Name
- Setmelanotide
- Synonyms
- UCB-0942;Setmelanotide;2-Pyrrolidinone, 4-(2-chloro-2,2-difluoroethyl)-1-[[2-(methoxymethyl)-6-(trifluoromethyl)imidazo[2,1-b]-1,3,4-thiadiazol-5-yl]methyl]-, (4R)-
- CBNumber
- CB33159977
- Molecular Formula
- C14H14ClF5N4O2S
- Formula Weight
- 432.8
- MOL File
- 1294000-61-5.mol
Setmelanotide Property
- Density
- 1.69±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 100 mg/mL (231.05 mM);Water : < 0.1 mg/mL (insoluble)
- pka
- -1.44±0.40(Predicted)
- form
- Solid
- color
- White to off-white
- InChI
- InChI=1S/C14H14ClF5N4O2S/c1-26-6-9-22-24-8(11(14(18,19)20)21-12(24)27-9)5-23-4-7(2-10(23)25)3-13(15,16)17/h7H,2-6H2,1H3/t7-/m1/s1
- InChIKey
- DCXFIOLWWRXEQH-SSDOTTSWSA-N
- SMILES
- N1(CC2N3N=C(COC)SC3=NC=2C(F)(F)F)C[C@@H](CC(Cl)(F)F)CC1=O
Setmelanotide Chemical Properties,Usage,Production
Uses
Padsevonil (UCB0942) is a potent antiepileptic agent that selectively acts on presynaptic and postsynaptic targets. Padsevonil binds to synaptic vesicular protein 2 (SV2) with high affinity. Padsevonil is also a positive allosteric modulator and partial agonist of GABAAR, with high potency against α1 and α5 receptors. Padsevonil has antiepileptic effects in a variety of rodent models[1][2].
in vivo
Padsevonil (0.014-181.4 mg/kg; intraperitoneal injection; single dose) has protective effects on the mouse model of acute epilepsy induced by 6Hz stimulation, acoustic stimulation and pilarine (HY-B0726A), with the ED50 values of 0.16, 0.17 and 0.19 mg/kg, respectively[2].
Padsevonil (0.14-30 mg/kg; intraperitoneal injection; single dose) has a protective effect in a rodent model of chronic epilepsy [2].
| Animal Model: | Kainate treated male C57BL/6 mice[2] |
| Dosage: | 1, 3, 10 and 30 mg/kg |
| Administration: | Intraperitoneal injection (i.p.); single dose |
| Result: | Significantly decreased the number of hippocampal paroxysmal discharges in dose-dependent manner. |
| Animal Model: | Platinum electrodes treated male Wistar rats[2] |
| Dosage: | 0.14, 0.43, 1.38 and 4.33 mg/kg |
| Administration: | Intraperitoneal injection (i.p.); single dose |
| Result: | Produced dose-related suppression in the cumulative duration of spontaneous spike and wave discharges, and the suppression was almost complete at a dose of 4.33 mg/kg. |
References
[1] Niespodziany I, et al. Functional characterization of the antiepileptic drug candidate, padsevonil, on GABAA receptors. Epilepsia. 2020 May;61(5):914-923. DOI:10.1111/epi.16497
[2] Leclercq K, et al. Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Characterization in Rodent Seizure and Epilepsy Models. J Pharmacol Exp Ther. 2020 Jan;372(1):11-20. DOI:10.1124/jpet.119.261222
Setmelanotide Preparation Products And Raw materials
Raw materials
Preparation Products
Setmelanotide Suppliers
- Tel
- 025-57798810
- Fax
- 025-57019371
- sales@sunlidabio.com
- Country
- China
- ProdList
- 3239
- Advantage
- 55
- Tel
- 18122150900
- Fax
- QQ:2869377561
- sculk28@163.com
- Country
- China
- ProdList
- 646
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9803
- Advantage
- 58
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32470
- Advantage
- 58
- Tel
- 86-571-88216897,88216896 13588875226
- Fax
- 86-571-88216895
- sales@hzclap.com
- Country
- CHINA
- ProdList
- 6312
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- +8618523575427
- sales@conier.com
- Country
- China
- ProdList
- 49977
- Advantage
- 58
- Tel
- 020-82000279 18988941452
- Fax
- QQ：3283937693
- YN_research@163.com
- Country
- China
- ProdList
- 3000
- Advantage
- 58
- Tel
- 13758194781 13173652190
- 522013271@qq.com
- Country
- China
- ProdList
- 2395
- Advantage
- 58
- Tel
- 1701086315
- Fax
- 1701086315@qq.com
- dexuanpharma@126.com
- Country
- China
- ProdList
- 9475
- Advantage
- 58
View Lastest Price from Setmelanotide manufacturers
- Product
- Setmelanotide
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-22
- Product
- Setmelanotide 1294000-61-5
- Price
- US $20.00/box
- Min. Order
- 1box
- Purity
- 99
- Supply Ability
- in stock
- Release date
- 2025-07-24
- Product
- Setmelanotide 1294000-61-5
- Price
- US $5.00/Box
- Min. Order
- 1Box
- Purity
- 99.99%
- Supply Ability
- 20000 boxes
- Release date
- 2025-07-10