Volixibat potassium
- Product Name
- Volixibat potassium
- CAS No.
- 220334-14-5
- Chemical Name
- Volixibat potassium
- Synonyms
- A-6 peptide;P1161 Angstrom6;Angstrom6 ，P1161;Volixibat potassium;Angstrom6/A6 Peptide;Volixibat potassium/A 6 (Peptide);A-6|||A 6 peptide|||A6|||A 6|||A6 peptide|||A-6 peptide;L-α-Glutamine, N2-acetyl-L-lysyl-L-prolyl-L-seryl-L-seryl-L-prolyl-L-prolyl-L-α-glutamyl-;(S)-N-((S)-1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-2-((S)-2-((S)-2-((S)-2-((S)-2-amino-3-phenylpropanamido)-3-hydroxypropanamido)-4-methylpentanamido)-4-methylpentanamido)-5-guanidinopentanamide
- CBNumber
- CB33160003
- Molecular Formula
- C39H62N10O15
- Formula Weight
- 910.98
- MOL File
- 220334-14-5.mol
Volixibat potassium Property
- Boiling point:
- 1469.3±65.0 °C(Predicted)
- Density
- 1.409±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- pka
- 4.44±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- Sequence
- Ac-Lys-Pro-Ser-Ser-Pro-Pro-Glu-Glu-NH2
N-Bromosuccinimide Price
- Product number
- CS-0114007
- Product name
- Angstrom6
- Purity
- 99.70%
- Packaging
- 5mg
- Price
- $205
- Updated
- 2021/12/16
- Product number
- CS-0114007
- Product name
- Angstrom6
- Purity
- 99.70%
- Packaging
- 10mg
- Price
- $350
- Updated
- 2021/12/16
Volixibat potassium Chemical Properties,Usage,Production
Uses
Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling[1][2].
in vivo
Angstrom6 (100 mg/kg; s.c. twice daily) reduces the number of lung foci generated by the i.v. injection of B16-F10 melanoma cells by 50%[3].
| Animal Model: | C57Bl/6 mice (bearing B16-F10 cells)[3] |
| Dosage: | 100 mg/kg |
| Administration: | S.c.; twice a day for 11 days |
| Result: | Reduced the number of lung nodules and reduced the number of lung metastases to 50% of control. |
References
[1] Ghamande SA, et al. A phase 2, randomized, double-blind, placebo-controlled trial of clinical activity and safety of subcutaneous A6 in women with asymptomatic CA125 progression after first-line chemotherapy of epithelial ovarian cancer. Gynecol Oncol. 2008;111(1):89-94. DOI:10.1016/j.ygyno.2008.06.028
[2] Finlayson M. Modulation of CD44 Activity by A6-Peptide. Front Immunol. 2015;6:135. Published 2015 Mar 30. DOI:10.3389/fimmu.2015.00135
[3] Piotrowicz RS, et al. A6 peptide activates CD44 adhesive activity, induces FAK and MEK phosphorylation, and inhibits the migration and metastasis of CD44-expressing cells. Mol Cancer Ther. 2011;10(11):2072-2082. DOI:10.1158/1535-7163.MCT-11-0351
Volixibat potassium Preparation Products And Raw materials
Raw materials
Preparation Products
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