Volixibat potassium

Product Name: Volixibat potassium
CAS No.: 220334-14-5
Chemical Name: Volixibat potassium
Synonyms: A-6 peptide;P1161 Angstrom6;Angstrom6 ，P1161;Volixibat potassium;Angstrom6/A6 Peptide;Volixibat potassium/A 6 (Peptide);A-6|||A 6 peptide|||A6|||A 6|||A6 peptide|||A-6 peptide;L-α-Glutamine, N2-acetyl-L-lysyl-L-prolyl-L-seryl-L-seryl-L-prolyl-L-prolyl-L-α-glutamyl-;(S)-N-((S)-1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-2-((S)-2-((S)-2-((S)-2-((S)-2-amino-3-phenylpropanamido)-3-hydroxypropanamido)-4-methylpentanamido)-4-methylpentanamido)-5-guanidinopentanamide
CBNumber: CB33160003
Molecular Formula: C39H62N10O15
Formula Weight: 910.98
MOL File: 220334-14-5.mol

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Volixibat potassium Property

Boiling point:: 1469.3±65.0 °C(Predicted)
Density: 1.409±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
pka: 4.44±0.10(Predicted)
form: Solid
color: White to off-white
Sequence: Ac-Lys-Pro-Ser-Ser-Pro-Pro-Glu-Glu-NH2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0114007
Product name: Angstrom6
Purity: 99.70%
Packaging: 5mg
Price: $205
Updated: 2021/12/16

ChemScene

Product number: CS-0114007
Product name: Angstrom6
Purity: 99.70%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

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Volixibat potassium Chemical Properties,Usage,Production

Uses

Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling[1][2].

in vivo

Angstrom6 (100 mg/kg; s.c. twice daily) reduces the number of lung foci generated by the i.v. injection of B16-F10 melanoma cells by 50%^[3].

Animal Model:	C57Bl/6 mice (bearing B16-F10 cells)^[3]
Dosage:	100 mg/kg
Administration:	S.c.; twice a day for 11 days
Result:	Reduced the number of lung nodules and reduced the number of lung metastases to 50% of control.

References

[1] Ghamande SA, et al. A phase 2, randomized, double-blind, placebo-controlled trial of clinical activity and safety of subcutaneous A6 in women with asymptomatic CA125 progression after first-line chemotherapy of epithelial ovarian cancer. Gynecol Oncol. 2008;111(1):89-94. DOI:10.1016/j.ygyno.2008.06.028
[2] Finlayson M. Modulation of CD44 Activity by A6-Peptide. Front Immunol. 2015;6:135. Published 2015 Mar 30. DOI:10.3389/fimmu.2015.00135
[3] Piotrowicz RS, et al. A6 peptide activates CD44 adhesive activity, induces FAK and MEK phosphorylation, and inhibits the migration and metastasis of CD44-expressing cells. Mol Cancer Ther. 2011;10(11):2072-2082. DOI:10.1158/1535-7163.MCT-11-0351

Volixibat potassium Preparation Products And Raw materials

Raw materials

Preparation Products

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Volixibat potassium Suppliers

China 36 United States 4 Global 40

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 40000
Advantage: 60

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9505
Advantage: 58

Chengdu Youngshe Chemical Co., Ltd.

Tel: +86-17380623303 +86-17380623303;
Fax: 028-62328193
Email: Caroline@youngshechem.com
Country: China
ProdList: 4801
Advantage: 58

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 7618
Advantage: 58

BOC Sciences

Tel: 16314854226; +16314854226
Email: inquiry@bocsci.com
Country: United States
ProdList: 19654
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32467
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471;
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Nanchang Tianzhen Biotechnology Co., Ltd

Tel: 13758194781 13173652190
Email: 522013271@qq.com
Country: China
ProdList: 2444
Advantage: 58

Wuxi Helen Biotechnology Co., Ltd.,

Tel: 0510-85629785 18013409632
Fax: 0510-85625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 14081
Advantage: 58

220334-14-5, Volixibat potassiumRelated Search:

Volixibat potassium

Angstrom6/A6 Peptide

A-6 peptide

L-α-Glutamine, N2-acetyl-L-lysyl-L-prolyl-L-seryl-L-seryl-L-prolyl-L-prolyl-L-α-glutamyl-

P1161 Angstrom6

A-6|||A 6 peptide|||A6|||A 6|||A6 peptide|||A-6 peptide

(S)-N-((S)-1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-2-((S)-2-((S)-2-((S)-2-((S)-2-amino-3-phenylpropanamido)-3-hydroxypropanamido)-4-methylpentanamido)-4-methylpentanamido)-5-guanidinopentanamide

Volixibat potassium/A 6 (Peptide)

Angstrom6 ，P1161

220334-14-5