ChemicalBook > CAS DataBase List > PE859

PE859

Product Name: PE859
CAS No.: 1402727-29-0
Chemical Name: PE859
Synonyms: PE859;PE-859; PE 859;PE859, 10 mM in DMSO;AMBZHNVCLPHAKA-NSJFVGFPSA-N;PE 859,PE-859,Inhibitor,inhibit,Microtubule/Tubulin,PE859;1H-Indole, 6-[(1E)-2-[5-[(1E)-2-[2-methoxy-4-(2-pyridinylmethoxy)phenyl]ethenyl]-1H-pyrazol-3-yl]ethenyl]-
CBNumber: CB33161550
Molecular Formula: C28H24N4O2
Formula Weight: 448.52
MOL File: 1402727-29-0.mol

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PE859 Property

Boiling point:: 747.7±60.0 °C(Predicted)
Density: 1.312±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (111.48 mM);Water : < 0.1 mg/mL (insoluble)
form: Solid
pka: 13.78±0.10(Predicted)
color: Light yellow to khaki
InChIKey: AMBZHNVCLPHAKA-NSJFVGFPSA-N
SMILES: N1C2=C(C=CC(/C=C/C3C=C(/C=C/C4=CC=C(OCC5=NC=CC=C5)C=C4OC)NN=3)=C2)C=C1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M267212
Product name: 6-((E)-2-(3-((E)-2-Methoxy-4-(pyridin-2-ylmethoxy)styryl)-1H-pyrazol-5-yl)vinyl)-1H-indole
Packaging: 2.5mg
Price: $800
Updated: 2021/12/16

ChemScene

Product number: CS-6428
Product name: PE859
Purity: 99.84%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-6428
Product name: PE859
Purity: 99.84%
Packaging: 1mg
Price: $132
Updated: 2021/12/16

ChemScene

Product number: CS-6428
Product name: PE859
Purity: 99.84%
Packaging: 5mg
Price: $396
Updated: 2021/12/16

ChemScene

Product number: CS-6428
Product name: PE859
Purity: 99.84%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

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PE859 Chemical Properties,Usage,Production

Uses

6-((E)-2-(3-((E)-2-Methoxy-4-(pyridin-2-ylmethoxy)styryl)-1H-pyrazol-5-yl)vinyl)-1H-indole is a potent tau aggregation inhibitor that functions as a drug for Alzheimer’s disease.

in vivo

PE859 could cross the blood-brain barrier and that PE859 could be distributed into the tissues of the central nervous system. The maximum concentration of PE859 is 2.005 μg/mL in the blood at 3 h and 1.428 μg/g in the brain at 6 h. PE859 delays onset and progression of the motor dysfunction in JNPL3 mice. PE859 delays progression of the motor dysfunction through the inhibition of accumulation of sarkosyl-insoluble tau. ^[2]

Enzyme inhibitor

This orally bioavailable tau aggregation inhibitor (FW = 448.53 g/mol; IUPAC: 3-[(1E)-2-(1H-indol-6-yl)ethenyl]-5-[(1E)-2-[2-methoxy-4-(2- pyridylmethoxy)phenyl]ethenyl]-1H-pyrazole) significantly reduces formation of sarkosyl-insoluble aggregates of Tau, the principal axonal microtubule-associated protein, and prevents onset and progression of the motor dysfunction in JNPL3 Pro-301-Leu-mutated human tau transgenic mice. PE859 also inhibits aggregation of three-repeat Tau, or 3RMBD-Tau (IC50 = 0.81 μM), and four-repeat Tau, or 2N4R-Tau (IC50 = 2.23 μM).

PE859 Preparation Products And Raw materials

Raw materials

Preparation Products

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1402727-29-0, PE859Related Search:

PE859

AMBZHNVCLPHAKA-NSJFVGFPSA-N

PE-859; PE 859

1H-Indole, 6-[(1E)-2-[5-[(1E)-2-[2-methoxy-4-(2-pyridinylmethoxy)phenyl]ethenyl]-1H-pyrazol-3-yl]ethenyl]-

PE 859,PE-859,Inhibitor,inhibit,Microtubule/Tubulin,PE859

PE859, 10 mM in DMSO

1402727-29-0