ChemicalBook > CAS DataBase List > KR-33494

KR-33494

Product Name
KR-33494
CAS No.
1021497-97-1
Chemical Name
KR-33494
Synonyms
KM-819;CS-2472;KR-33494;KR-33493;KR-33494 ，E2361;KR33494;KR 33494;KR-33493, 10 mM in DMSO;4-(2-(4-bromophenylthio)acetamido)-1-phenethyl-1H-pyrazole-3-carboxylic acid;4-[2-(4-bromo-phenylsulfanyl)-acetylamino]-1-phenethyl-1H-pyrazole-3-carboxylic acid;4-[[2-[(4-Bromophenyl)thio]acetyl]amino]-1-(2-phenylethyl)-1H-pyrazole-3-carboxylic acid
CBNumber
CB33164788
Molecular Formula
C20H18BrN3O3S
Formula Weight
460.34
MOL File
1021497-97-1.mol
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KR-33494 Property

storage temp. 
Store at -20°C
solubility 
DMSO:61.5(Max Conc. mg/mL);133.6(Max Conc. mM)
form 
A crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22071
Product name
KR-33494
Packaging
1mg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
22071
Product name
KR-33494
Packaging
5mg
Price
$410
Updated
2024/03/01
Cayman Chemical
Product number
22071
Product name
KR-33494
Packaging
10mg
Price
$721
Updated
2024/03/01
Cayman Chemical
Product number
22071
Product name
KR-33494
Packaging
25mg
Price
$1199
Updated
2024/03/01
AK Scientific
Product number
2477DC
Product name
4-[[2-(4-Bromophenyl)sulfanylacetyl]amino]-1-(2-phenylethyl)pyrazole-3-carboxylicacid
Packaging
1mg
Price
$206
Updated
2021/12/16
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KR-33494 Chemical Properties,Usage,Production

Uses

KR-33493 is a potent inhibitor of Fas-mediated cell death (FAF1).

in vivo

Body weight changes of both sexes are not related to KR-33493 in all doses. In rats administrated KR-33493 for 4 weeks, no test article-related changes in any treated groups of either sex are found in hematology, serum biochemistry, and urinalysis. In dogs administrated KR-33493 for 2 weeks, red blood cell count (RBC) value in males is significantly higher at the 1000 mg/kg/day dose than that of the control group (i.e., 6.96±0.323 vs. 6.12±0.418). However, the change of RBC is recovered after the end of the administration period. The dose-normalized AUClast is not significantly different between the groups, suggesting that KR-33493 is governed by linear kinetics[1].

IC 50

Fas

References

[1] Jeong JW, et al. Subacute toxicity evaluation of KR-33493, FAF1 inhibitor for a new anti-parkinson's disease agent, after oral administration in rats and dogs. Regul Toxicol Pharmacol. 2016 Nov;81:387-396. DOI:10.1016/j.yrtph.2016.09.022

KR-33494 Preparation Products And Raw materials

Raw materials

Preparation Products

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KR-33494 Suppliers

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View Lastest Price from KR-33494 manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd
Product
KR-33494 1021497-97-1
Price
US $100.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2021-09-13
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
KR-33494 1021497-97-1
Price
US $100.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
10kg
Release date
2021-09-15
Zhejiang J&C Biological Technology Co.,Limited
Product
KR-33494 1021497-97-1
Price
US $0.00/gram
Min. Order
1gram
Purity
99%
Supply Ability
10kg
Release date
2022-02-17

1021497-97-1, KR-33494Related Search:


  • KR-33494
  • 4-(2-(4-bromophenylthio)acetamido)-1-phenethyl-1H-pyrazole-3-carboxylic acid
  • KR-33493
  • 4-[2-(4-bromo-phenylsulfanyl)-acetylamino]-1-phenethyl-1H-pyrazole-3-carboxylic acid
  • CS-2472
  • KR33494;KR 33494
  • KM-819
  • 1H-Pyrazole-3-carboxylic acid, 4-[[2-[(4-bromophenyl)thio]acetyl]amino]-1-(2-phenylethyl)-
  • 4-[[2-[(4-Bromophenyl)thio]acetyl]amino]-1-(2-phenylethyl)-1H-pyrazole-3-carboxylic acid
  • KR-33493, 10 mM in DMSO
  • KR-33494 ，E2361
  • 1021497-97-1