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ASP5878

Product Name
ASP5878
CAS No.
1453208-66-6
Chemical Name
ASP5878
Synonyms
ASP5878;ASP-5878 (ASP5878;ASP5878, 10 mM in DMSO;ASP5878; ASP 5878; ASP-5878;ASP 5878,Inhibitor,FGFR,ASP5878,Fibroblast growth factor receptor,inhibit;1H-Pyrazole-1-ethanol, 4-[[5-[(2,6-difluoro-3,5-dimethoxyphenyl)methoxy]-2-pyrimidinyl]amino]-;2-(4-((5-((2,6-Difluoro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)ethan-1-ol
CBNumber
CB33164874
Molecular Formula
C18H19F2N5O4
Formula Weight
407.37
MOL File
1453208-66-6.mol
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ASP5878 Property

Boiling point:
645.3±65.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 250 mg/mL (613.69 mM);Water : < 0.1 mg/mL (insoluble)
pka
14.41±0.10(Predicted)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
A788595
Product name
ASP5878
Packaging
1mg
Price
$285
Updated
2021/12/16
TRC
Product number
A788595
Product name
ASP5878
Packaging
2.5mg
Price
$615
Updated
2021/12/16
ChemScene
Product number
CS-0017707
Product name
ASP5878
Purity
99.71%
Packaging
5mg
Price
$450
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0009816
Product name
ASP-5878
Purity
95.00%
Packaging
5MG
Price
$454.83
Updated
2021/12/16
ChemScene
Product number
CS-0017707
Product name
ASP5878
Purity
99.71%
Packaging
10mg
Price
$750
Updated
2021/12/16
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ASP5878 Chemical Properties,Usage,Production

Uses

ASP5878 is a selective inhibitor of FGFR1, 2, 3 and 4.

in vivo

ASP5878 (3 mg/kg, orally, once daily) shows antitumor activity in a Hep3B2.1-7 subcutaneous xenograft? and HCC orthotopic xenograft mouse model[1].
? ASP5878 induces shrinkage of FGF19-expressing HCC xenograft model[1].

Animal Model:Four-week-old male nude mice (CAnN.Cg-Foxn1nu/CrlCrlj [nu/nu]) (Hep3B2.1-7 cells inoculated subcutaneously)[1].
Dosage:3 mg/kg.
Administration:Orally once daily from days 14 to 52.
Result:Induced tumor regression by 9% and 88% at 1 and 3 mg/kg, respectively, without affecting the body weight for 14 days.
Induced the suppression of FGFR4 phosphorylation, mobility shift of FRS2, and suppression of ERK phosphorylation.
Animal Model:HCC orthotopic xenograft model (mouse)[1].
Dosage:3 mg/kg.
Administration:Orally once daily for 24 days.
Result:Exhibited a lower tumor burden than vehicle- and sorafenibtreated mice.
Induced sustained tumor regression without tumor regrowth.

IC 50

FGFR1: 0.47 nM (IC50); FGFR2: 0.6 nM (IC50); FGFR3: 0.74 nM (IC50); FGFR4: 3.5 nM (IC50)

ASP5878 Preparation Products And Raw materials

Raw materials

Preparation Products

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ASP5878 Suppliers

China 47 United States 5 Global 52
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
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65
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9126
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58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
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58

1453208-66-6, ASP5878Related Search:


  • ASP5878
  • ASP-5878 (ASP5878
  • ASP5878; ASP 5878; ASP-5878
  • ASP 5878,Inhibitor,FGFR,ASP5878,Fibroblast growth factor receptor,inhibit
  • 1H-Pyrazole-1-ethanol, 4-[[5-[(2,6-difluoro-3,5-dimethoxyphenyl)methoxy]-2-pyrimidinyl]amino]-
  • 2-(4-((5-((2,6-Difluoro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)ethan-1-ol
  • ASP5878, 10 mM in DMSO
  • 1453208-66-6