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ASP5878

Product Name
ASP5878
CAS No.
1453208-66-6
Chemical Name
ASP5878
Synonyms
ASP5878;ASP-5878 (ASP5878;ASP5878, 10 mM in DMSO;ASP5878; ASP 5878; ASP-5878;ASP 5878,Inhibitor,FGFR,ASP5878,Fibroblast growth factor receptor,inhibit;1H-Pyrazole-1-ethanol, 4-[[5-[(2,6-difluoro-3,5-dimethoxyphenyl)methoxy]-2-pyrimidinyl]amino]-;2-(4-((5-((2,6-Difluoro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)ethan-1-ol
CBNumber
CB33164874
Molecular Formula
C18H19F2N5O4
Formula Weight
407.37
MOL File
1453208-66-6.mol
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ASP5878 Property

Boiling point:
645.3±65.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 250 mg/mL (613.69 mM);Water : < 0.1 mg/mL (insoluble)
pka
14.41±0.10(Predicted)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
A788595
Product name
ASP5878
Packaging
1mg
Price
$285
Updated
2021/12/16
TRC
Product number
A788595
Product name
ASP5878
Packaging
2.5mg
Price
$615
Updated
2021/12/16
ChemScene
Product number
CS-0017707
Product name
ASP5878
Purity
99.71%
Packaging
10mg
Price
$750
Updated
2021/12/16
ChemScene
Product number
CS-0017707
Product name
ASP5878
Purity
99.71%
Packaging
5mg
Price
$450
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0009816
Product name
ASP-5878
Purity
95.00%
Packaging
5MG
Price
$454.83
Updated
2021/12/16
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ASP5878 Chemical Properties,Usage,Production

Uses

ASP5878 is a selective inhibitor of FGFR1, 2, 3 and 4.

in vivo

ASP5878 (3 mg/kg, orally, once daily) shows antitumor activity in a Hep3B2.1-7 subcutaneous xenograft and HCC orthotopic xenograft mouse model[1].
ASP5878 induces shrinkage of FGF19-expressing HCC xenograft model[1].

Animal Model:Four-week-old male nude mice (CAnN.Cg-Foxn1nu/CrlCrlj [nu/nu]) (Hep3B2.1-7 cells inoculated subcutaneously)[1].
Dosage:3 mg/kg.
Administration:Orally once daily from days 14 to 52.
Result:Induced tumor regression by 9% and 88% at 1 and 3 mg/kg, respectively, without affecting the body weight for 14 days.
Induced the suppression of FGFR4 phosphorylation, mobility shift of FRS2, and suppression of ERK phosphorylation.
Animal Model:HCC orthotopic xenograft model (mouse)[1].
Dosage:3 mg/kg.
Administration:Orally once daily for 24 days.
Result:Exhibited a lower tumor burden than vehicle- and sorafenibtreated mice.
Induced sustained tumor regression without tumor regrowth.

IC 50

FGFR1: 0.47 nM (IC50); FGFR2: 0.6 nM (IC50); FGFR3: 0.74 nM (IC50); FGFR4: 3.5 nM (IC50)

ASP5878 Preparation Products And Raw materials

Raw materials

Preparation Products

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ASP5878 Suppliers

China 48 United States 5 Global 53
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
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65
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3505
Advantage
58
Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4827
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9532
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
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58

1453208-66-6, ASP5878Related Search:


  • ASP5878
  • ASP-5878 (ASP5878
  • ASP5878; ASP 5878; ASP-5878
  • ASP 5878,Inhibitor,FGFR,ASP5878,Fibroblast growth factor receptor,inhibit
  • 1H-Pyrazole-1-ethanol, 4-[[5-[(2,6-difluoro-3,5-dimethoxyphenyl)methoxy]-2-pyrimidinyl]amino]-
  • 2-(4-((5-((2,6-Difluoro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)ethan-1-ol
  • ASP5878, 10 mM in DMSO
  • 1453208-66-6