ChemicalBook > CAS DataBase List > TNU9056
TNU9056
- Product Name
- TNU9056
- CAS No.
- 1450644-28-6
- Chemical Name
- TNU9056
- Synonyms
- TNU9056;Isothiazole, 5,5'-dithiobis-;NU 9056, KAT5 (Tip60) inhibitor;1,2-Di(isothiazol-5-yl)disulfane;NU9056 1,2-Bis(isothiazol-5-yl)disulfane;TNU9056 1,2-Di(isothiazol-5-yl)disulfane;5-(1,2-thiazol-5-yldisulfanyl)-1,2-thiazole
- CBNumber
- CB33165811
- Molecular Formula
- C6H4N2S4
- Formula Weight
- 232.37
- MOL File
- 1450644-28-6.mol
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TNU9056 Property
- Boiling point:
- 209.2±40.0 °C(Predicted)
- Density
- 1.60±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- <10mg/ml in DMSO
- form
- Liquid
- pka
- 2.44±0.38(Predicted)
- color
- Yellow to brown
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 5.00511
- Product name
- Histone Acetyltransferase Inhibitor VIII, NU9056
- Packaging
- 10 mg
- Price
- $259
- Updated
- 2025/07/31
TRC
- Product number
- N925310
- Product name
- NU9056
- Packaging
- 5mg
- Price
- $70
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A4492
- Product name
- 1,2-di(isothiazol-5-yl)disulfane
- Packaging
- 10mg
- Price
- $223
- Updated
- 2021/12/16
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TNU9056 Chemical Properties,Usage,Production
Uses
NU 9056 is a selective KAT5 (Tip60) histone acetyltransferase inhibitor. It inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Iy decreases proliferation of LNCaP cells and induces apoptosis via caspase activation.
Biological Activity
Cell permeable: yes', 'Primary Target
KAT5', 'Reversible: yes
in vivo
The mice are injected with Nu9056 (2 μg/g) and the hippocampus is collected 1 h later. Tip60 inhibition reduces H2A.Z binding at the -1 nucleosome of Arc, and the +1 nucleosome of Arc and Syp. Additionally, Nu9056 increases acetylation at the -1 nucleosome of Fos, Tacstd2, and Gria4, and the +1 nucleosome of Gria4[2].
storage
Store at -20°C
TNU9056 Preparation Products And Raw materials
Raw materials
Preparation Products
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