ChemicalBook > CAS DataBase List > CC220

CC220

Product Name
CC220
CAS No.
1323403-33-3
Chemical Name
CC220
Synonyms
CC220;CS-2470;Iberdomide;CC-220 Iberdomide;Iberdomide(CC220);CC220; CC 220; CC-220;Iberdomide, 10 mM in DMSO;Iberdomide (CC220) ，S8760;(S)-3-(4-((4-(Morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione;(S)-3-(4-((4-(Morpholin-4-ylmethyl)-benzyloxy))-1-oxoisoindolin-2-yl)piperidin-2,6-dione
CBNumber
CB33170516
Molecular Formula
C25H27N3O5
Formula Weight
449.5
MOL File
1323403-33-3.mol
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CC220 Property

Boiling point:
717.8±60.0 °C(Predicted)
Density 
1.332±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:125.0(Max Conc. mg/mL);278.09(Max Conc. mM)
form 
A crystalline solid
pka
10.70±0.40(Predicted)
color 
White to off-white
InChIKey
IXZOHGPZAQLIBH-NRFANRHFSA-N
SMILES
N1C(=O)CC[C@H](N2CC3=C(C2=O)C=CC=C3OCC2=CC=C(CN3CCOCC3)C=C2)C1=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22615
Product name
Iberdomide
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
22615
Product name
Iberdomide
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
22615
Product name
Iberdomide
Purity
≥98%
Packaging
10mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
22615
Product name
Iberdomide
Purity
≥98%
Packaging
25mg
Price
$533
Updated
2024/03/01
AK Scientific
Product number
4100DT
Product name
Iberdomide
Packaging
5mg
Price
$252
Updated
2021/12/16
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CC220 Chemical Properties,Usage,Production

Uses

Iberdomide (CC-220) is an orally active and potent cereblon (CRBN) E3 ligase modulator (CELMoD) with an IC50 of ~150?nM for cereblon-binding affinity. Iberdomide, a derivative of Thalidomide (HY-14658), has antitumor and immunostimulatory activities[1][2].

in vivo

Iberdomide (CC-220; 10 mg/kg; oral gavage) after 6 or 24 hours causes higher hCRBN expression in hC343 splenocytes correlated to deeper IKZF1/3 downregulation in WT (C57BL/6), hC123, or-343, (representing two different transgenic founder lines expressing hCRBN) and mCrbn-/- mice[2].

IC 50

Cereblon

References

[1] Chad C Bjorklund, et al. Iberdomide (CC-220) is a potent cereblon E3 ligase modulator with antitumor and immunostimulatory activities in lenalidomide- and pomalidomide-resistant multiple myeloma cells with dysregulated CRBN. Leukemia. 2020 Apr;34(4):1197-1201. DOI:10.1038/s41375-019-0620-8
[2] Erin W Meermeier, et al. Tumor burden limits bispecific antibody efficacy through T cell exhaustion averted by concurrent cytotoxic therapy. Blood Cancer Discov. 2021 Jul;2(4):354-369. DOI:10.1158/2643-3230.BCD-21-0038

CC220 Preparation Products And Raw materials

Raw materials

Preparation Products

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CC220 Suppliers

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View Lastest Price from CC220 manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Iberdomide 1323403-33-3
Price
US $0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2021-09-13
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Iberdomide 1323403-33-3
Price
US $100.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
10kg
Release date
2021-09-15
Career Henan Chemical Co
Product
CC220 1323403-33-3
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2019-12-26

1323403-33-3, CC220Related Search:


  • CC-220 Iberdomide
  • CC220
  • (S)-3-[4-(4-morpholin-4-yl-methyl-benzyloxy)-1-oxo-1,3-dihydro-isoindol-2-yl]-piperidine-2,6-dione
  • Iberdomide
  • Iberdomide(CC220)
  • CS-2470
  • CC220; CC 220; CC-220
  • 2,6-Piperidinedione, 3-[1,3-dihydro-4-[[4-(4-morpholinylmethyl)phenyl]methoxy]-1-oxo-2H-isoindol-2-yl]-, (3S)-
  • (S)-3-(4-((4-(Morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
  • CELMoD,H929,CRBN,Ligands for E3 Ligase,KMS12PE,KMS11,orally,sub-G1,Apoptosis,Iberdomide,cereblon,G0/G1,U266,multiple,ligase,Inhibitor,Thalidomide,RPM-8226,MM1.R,MM1.S,CC220,EJM,KMS128M,CC 220,inhibit,E3 ligase-recruiting Moiety,myeloma
  • Iberdomide, 10 mM in DMSO
  • Iberdomide (CC220) ，S8760
  • (S)-3-(4-((4-(Morpholin-4-ylmethyl)-benzyloxy))-1-oxoisoindolin-2-yl)piperidin-2,6-dione
  • 1323403-33-3