FMK 9a

Product Name: FMK 9a
CAS No.: 1955550-51-2
Chemical Name: FMK 9a
Synonyms: FMK 9a;FMK-9A; FMK9A;FMK 9a, 10 mM in DMSO;inhibit,FMK 9a,Autophagy,Inhibitor;FMK 9a New;(2S)-N-(3-fluoro-2-oxopropyl)-2-[(naphthalen-1-yl)formamido]-3-phenylpropanamide;1-Naphthalenecarboxamide, N-[(1S)-2-[(3-fluoro-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-
CBNumber: CB33171694
Molecular Formula: C23H21FN2O3
Formula Weight: 392.42
MOL File: 1955550-51-2.mol

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FMK 9a Property

Boiling point:: 724.6±60.0 °C(Predicted)
Density: 1.241±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO: 100 mg/mL (254.83 mM)
pka: 12.82±0.46(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC10194
Product name: FMK9a
Purity: >98%
Packaging: 250mg
Price: $3000
Updated: 2021/12/16

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FMK 9a Chemical Properties,Usage,Production

Uses

FMK 9a is an autophagin-1 inhibitor with IC50 values of 80 and 73 μM in FRET and LRA assay.

in vivo

FMK 9a shows moderate solubility (LYSA: 41 μg/mL) and high human and mouse liver microsome clearances of 13.9 and 70 mL/kg per minute^[1].

References

[1] Qiu Z, et al. Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors. ACS Med Chem Lett. 2016 Jun 25;7(8):802-6. DOI:10.1021/acsmedchemlett.6b00208

FMK 9a Preparation Products And Raw materials

Raw materials

Preparation Products

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FMK 9a Suppliers

China 30 United States 2 USA 1 Global 33

Nanjing Chemlin Chemical Co., Ltd

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1955550-51-2, FMK 9aRelated Search:

FMK-9A; FMK9A

FMK 9a

1-Naphthalenecarboxamide, N-[(1S)-2-[(3-fluoro-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-

inhibit,FMK 9a,Autophagy,Inhibitor

(2S)-N-(3-fluoro-2-oxopropyl)-2-[(naphthalen-1-yl)formamido]-3-phenylpropanamide

FMK 9a New

FMK 9a, 10 mM in DMSO

1955550-51-2