Boc-Val-Cit-PAB-PNP

Product Name: Boc-Val-Cit-PAB-PNP
CAS No.: 870487-10-8
Chemical Name: Boc-Val-Cit-PAB-PNP
Synonyms: BOC-Val-cit-pab;Boc-Val-Cit-PAB-PNP;Boc-Val-Cit-PAB-PNB;Boc-Val-Cit-PABC-PNP;Benzeneethanol,6-iodo-;t-Butyloxycarbonyl-valyl-citrullyl-(4-aminobenzyl)-(4-nitrophenyl)carbonate;inhibit,Antibody-drug conjugates linkers,BocValCitPABPNP,ADC Linkers,Boc Val Cit PAB PNP,Inhibitor;4-[(S)-2-[(S)-2-(Boc-amino)-3-methylbutanamido]-5-ureidopentanamido]benzyl (4-Nitrophenyl) carbonate;L-Ornithinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-;4-[[(2S)-2-[[(2S)-2-(tert-butoxycarbonylamino)-3-methyl-butanoyl]amino]-5-ureido-pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
CBNumber: CB33172833
Molecular Formula: C30H40N6O10
Formula Weight: 644.67
MOL File: 870487-10-8.mol

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Boc-Val-Cit-PAB-PNP Property

Boiling point:: 896.0±65.0 °C(Predicted)
Density: 1.291±0.06 g/cm3(Predicted)
storage temp.: -20°C, stored under nitrogen, away from moisture
solubility: DMSO : 250 mg/mL (387.80 mM; Need ultrasonic)
pka: 11.25±0.46(Predicted)
form: Solid
color: White to off-white
InChIKey: PJCUTAUEMJZDQD-ZEQRLZLVSA-N
SMILES: C(N)(=O)[C@H](CCCNC(N)=O)N(C(=O)[C@H](C(C)C)NC(OC(C)(C)C)=O)C1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Iris Biotech GmbH

Product number: ADC1010
Product name: Boc-Val-Cit-PAB-PNP
Packaging: 100mg
Price: $168.75
Updated: 2021/12/16

BroadPharm

Product number: BP-24175
Product name: Boc-Val-Cit-PAB-PNP
Purity: 95%
Packaging: 250mg
Price: $300
Updated: 2021/12/16

Iris Biotech GmbH

Product number: ADC1010
Product name: Boc-Val-Cit-PAB-PNP
Packaging: 250mg
Price: $337.5
Updated: 2021/12/16

Activate Scientific

Product number: AS106848
Product name: Boc-Val-Cit-PAB-PNP
Purity: 97%
Packaging: 250mg
Price: $714
Updated: 2021/12/16

Iris Biotech GmbH

Product number: ADC1010
Product name: Boc-Val-Cit-PAB-PNP
Packaging: 1g
Price: $1012.5
Updated: 2021/12/16

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Boc-Val-Cit-PAB-PNP Chemical Properties,Usage,Production

Description

Boc-Val-Cit-PAB-PNB is a cleavable peptide ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell.PNP can be substituted by amine bearing molecules.

Uses

Boc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC 50

Protease Cleavable Linker; Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

Boc-Val-Cit-PAB-PNP Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-Val-Cit-PAB-PNP Suppliers

China 86 United States 5 Global 91

Shenzhen Yuzhong Pharmaceutical Technology Co., Ltd.

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SuZhou JianHua Pharmaceutical Co. Ltd

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ShangHai Biochempartner Co.,Ltd

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Heze Development Zone chuangli Chemical Co., Ltd.

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Country: China
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Shanghai Topbiochem Technology Co., Ltd

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Shanghai Macklin Biochemical Co.,Ltd.

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Hangzhou J&H Chemical Co., Ltd.

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Shanghai Send Pharmaceutical Technology Co., Ltd.

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Country: China
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View Lastest Price from Boc-Val-Cit-PAB-PNP manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Boc-Val-Cit-PAB-PNP 870487-10-8
Price: US $0.00/g
Min. Order: 1g
Purity: >99.00%
Supply Ability: 1g
Release date: 2024-03-29

870487-10-8, Boc-Val-Cit-PAB-PNPRelated Search:

Boc-Val-Cit-PAB-PNP

BOC-Val-cit-pab

tert-butyl ((5)-3-methyl-1-(((5)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-1-oxobutan-2-yl)carbamate

Boc-Val-Cit-PABC-PNP

Boc-Val-Cit-PAB-PNB

L-Ornithinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-

t-Butyloxycarbonyl-valyl-citrullyl-(4-aminobenzyl)-(4-nitrophenyl)carbonate

Benzeneethanol,6-iodo-

tert-Butyl ((S)-3-methyl-1-(((S)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-1-oxobutan-2-yl)carbamate

inhibit,Antibody-drug conjugates linkers,BocValCitPABPNP,ADC Linkers,Boc Val Cit PAB PNP,Inhibitor

4-[[(2S)-2-[[(2S)-2-(tert-butoxycarbonylamino)-3-methyl-butanoyl]amino]-5-ureido-pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate

4-[(S)-2-[(S)-2-(Boc-amino)-3-methylbutanamido]-5-ureidopentanamido]benzyl (4-Nitrophenyl) carbonate

[4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoyl]amino]pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate

870487-10-8

C30H40N6O10

Linker

ADC LINKER

ADCs