ChemicalBook > CAS DataBase List > 5-Hydroxy-2-nitrobenzaldehyde

5-Hydroxy-2-nitrobenzaldehyde

Product Name
5-Hydroxy-2-nitrobenzaldehyde
CAS No.
42454-06-8
Chemical Name
5-Hydroxy-2-nitrobenzaldehyde
Synonyms
3-Formyl-4-nitrophenol;LABOTEST-BB LT00233113;5-Hydroxy-2-nitrobenzaL;2-NITRO-5-HYDROXYBENZALDE;5-Hydroxy-2-nitrobenzaldehy;3-HYDROXY-6-NITROBENZALDEHYDE;5-HYDROXY-2-NITROBENZALDEHYDE;6-NITRO-3-HYDROXY BENZALDHYDE;6-NITRO-3-HYDROXYBENZALDEHYDE;2-NITRO-5-HYDROXYBENZALDEHYDE
CBNumber
CB3318890
Molecular Formula
C7H5NO4
Formula Weight
167.12
MOL File
42454-06-8.mol
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5-Hydroxy-2-nitrobenzaldehyde Property

Melting point:
165-169 °C (lit.)
Boiling point:
373.0±32.0 °C(Predicted)
Density 
1.500±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in methanol.
pka
6.34±0.10(Predicted)
form 
Solid
color 
Pale Yellow to Yellow
Sensitive 
Air Sensitive
BRN 
1910196
Stability:
Air Sensitive
CAS DataBase Reference
42454-06-8(CAS DataBase Reference)
NIST Chemistry Reference
5-Hydroxy-2-nitro-benzaldehyde(42454-06-8)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
CU6700000
HS Code 
29130000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H48107
Product name
5-Hydroxy-2-nitrobenzaldehyde
Purity
98%
Packaging
5g
Price
$108.3
Updated
2025/07/31
Sigma-Aldrich
Product number
H48107
Product name
5-Hydroxy-2-nitrobenzaldehyde
Purity
98%
Packaging
25g
Price
$149.15
Updated
2025/07/31
TCI Chemical
Product number
H1039
Product name
5-Hydroxy-2-nitrobenzaldehyde
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$113
Updated
2025/07/31
TCI Chemical
Product number
H1039
Product name
5-Hydroxy-2-nitrobenzaldehyde
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$352
Updated
2025/07/31
TRC
Product number
H941005
Product name
5-Hydroxy-2-nitrobenzaldehyde
Packaging
10g
Price
$130
Updated
2021/12/16
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5-Hydroxy-2-nitrobenzaldehyde Chemical Properties,Usage,Production

Chemical Properties

Yellow powder

Uses

5-Hydroxy-2-nitrobenzaldehyde is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Synthesis Reference(s)

The Journal of Organic Chemistry, 44, p. 409, 1979 DOI: 10.1021/jo01317a021

Synthesis

100-83-4

42454-06-8

The general procedure for the synthesis of 5-hydroxy-2-nitrobenzaldehyde (formula VI) using m-hydroxybenzaldehyde (formula V, R5=H) as starting material was as follows: 3 g of m-hydroxybenzaldehyde was slowly added to 30 ml of nitric acid (density = 1.17, 28% solution), and the temperature of the solution was maintained at a temperature between 35°C and 45°C during the reaction. After the addition was completed, hydrolysis was carried out and the reaction mixture was subsequently left to stand at room temperature. The reaction produced a yellow precipitate which was filtered and the precipitate was refluxed in 20 ml of benzene for 15 to 20 minutes. The insoluble material was separated and purified by recrystallization in water. 5-Hydroxy-2-nitrobenzaldehyde (formula VI) was finally obtained in 25% yield with a melting point of 167°C (molecular formula: C7H5NO4, molecular weight = 167).

References

[1] Helvetica Chimica Acta, 1992, vol. 75, # 4, p. 1185 - 1197
[2] Patent: US5139707, 1992, A
[3] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 3, p. 444 - 452
[4] Journal of the Chemical Society, 1925, vol. 127, p. 2171
[5] Journal of the Chemical Society, 1925, vol. 127, p. 876,877

5-Hydroxy-2-nitrobenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Hydroxy-2-nitrobenzaldehyde Suppliers

Americas 1 CHINA 142 Europe 3 France 1 Germany 7 India 17 Japan 3 Switzerland 3 Ukraine 2 United Kingdom 16 United States 45 Global 240
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View Lastest Price from 5-Hydroxy-2-nitrobenzaldehyde manufacturers

Shaanxi Didu New Materials Co. Ltd
Product
5-Hydroxy-2-nitrobenzaldehyde 42454-06-8
Price
US $1.50/g
Min. Order
1g
Purity
99.0% Min
Supply Ability
100 Tons
Release date
2025-09-25
Hebei Chuanghai Biotechnology Co., Ltd
Product
5-Hydroxy-2-nitrobenzaldehyde 42454-06-8
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-12
Shaanxi Dideu Medichem Co. Ltd
Product
5-Hydroxy-2-nitrobenzaldehyde 42454-06-8
Price
US $0.00-0.00/KG
Min. Order
10mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-15

42454-06-8, 5-Hydroxy-2-nitrobenzaldehydeRelated Search:

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  • 42454-06-8
  • HOC6H3NO2CHO
  • ALDEHYDE
  • Organic Building Blocks
  • Aldehydes
  • Carbonyl Compounds
  • C7
  • Building Blocks
  • Carbonyl Compounds
  • Chemical Synthesis
  • Organic Building Blocks
  • Building Blocks
  • Aromatic Aldehydes & Derivatives (substituted)
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